N-(2-hydroxypropyl)benzenesulphonamide

Endpoint summary

Description of key information

The acute oral LD50 of the test material in the wistar rat was determined to be >2000 mg/kg bodyweight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

female

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

dose vomume was maintained at 10ml/kg b.w.

Doses:

2000mg/kg b.w.

Control animals:

no

Details on study design:

In a limit test, one overnight fasted female rat was administered orally 2000 mg/kg b.w. of the test substa,nce mixed with corn oil. As the animal survived four additional animals were dosed sequentially with the same dose of 2000mg/kg b.w .Each time a signal aniaml was dosed.
Following dosing, rats were observed for14 days for mortality and clinical signs of toxicity. body weigts of animal were noted at t the start of the experiment and weekly. A gross necropsy wa perfprmed an all animals on day 14

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No mortality was observed

Clinical signs:

other: No cliniclas signs of toxicity was observed

Gross pathology:

no macroscopic lesions

Other findings:

no

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 of N-n(2-hydroxypropyl)benzensulphonamide was determined to be >2000mg/kg b.w fot wistar rat under the experimental conditions tested

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because skin contact in production and/or use is not likely

Justification for classification or non-classification

Based on these results and according to the EC Directive (No.93/21/EEC) and CLP (No. 1272/2008 of 16 December 2008), N-n-(2 -hydroxylpropyl) benzenesulphonamide does not have to be classified and has no obligatory labelling requirement for oral toxicity.