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Diss Factsheets
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EC number: 208-403-5 | CAS number: 526-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,4,5,6-Tetrahydroxy-2-oxo-hexanoicacid
- IUPAC Name:
- 3,4,5,6-Tetrahydroxy-2-oxo-hexanoicacid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino rabbit; Crt: KBL (NZW) BR
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River, KiBlegg
- Age at study initiation: 14 weeks
- Weight at study initiation: 3.05 kg
- Housing: The animals were housed in air conditioned rooms at the Institute of Toxicology.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Humidity (%): 59-75%
- Photoperiod (hrs dark / hrs light): 12 hours dark/12 hours light
IN-LIFE DATES: From: June 5, 1997 To: July 17, 1997
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- The eye was examined after 1 hour of treatment, 24, 48, 72 hours and then daily up through day 22 of the experimental part. Body weight was recorded on day 1 and also on days 5, 8, 11, 15, and 22.
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 3.75
- Max. score:
- 4
- Reversibility:
- other: partially reversible from 4 to 2 at about 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 3 days after first observation
- Remarks on result:
- other: The iris was not visible up to day 5
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 1.25 - 2.25
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- The mean scored for the iris could not be determined as the iris was not visible until day 5 of the study.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material is considered to be an eye irritant for regulatory purposes. The weight of the rabbit increased from 3.05 kg to 3.51 over the course of the study period.
- Executive summary:
This study examined the potential of the test substance to cause irritation to eyes. 0.1 g of test substance was placed in one eye of one female rabbit. The untreated eye served as control. The animals were examined for signs of irritation at 1, 24, 48, and 72 hours, as well as daily up until day 22 after application. The mean score for the cornea was 3.75, while the mean score for the iris was not determined as it was not able to be seen until day 5 of the study. The mean conjunctivae scores were 1.25 and 2.25 for A and B, respecitively. The test substance is classified as an eye irritant under EU GHS guidelines.
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