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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 3,7-DIMETHYLOCTANYL ACETATE
Author:
Edited by D.L.J Opydke
Year:
1980
Bibliographic source:
Food and Cosmetics Toxicology, Volume 18, Issue 6, 1980, Page 673

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of the given test chemical in humans.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyl-1-octyl acetate
EC Number:
244-034-6
EC Name:
3,7-dimethyl-1-octyl acetate
Cas Number:
20780-49-8
Molecular formula:
C12H24O2
IUPAC Name:
3,7-dimethyl-1-octyl acetate
Test material form:
liquid
Details on test material:
Name of test material (as cited in study report): Dihydrocitronellyl acetate
IUPAC name: 3,7-dimethyl-1-octyl acetate
Molecular formula: C12H24O2
Molecular weight: 200.32 g/mol
Smiles notation: C([C@@H](CCOC(C)=O)C)CCC(C)C
InChl: 1S/C12H24O2/c110(2)65711(3)891412(v4)13/h1011H,59H2,14H3
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of test material (as cited in study report): Dihydrocitronellyl acetate
IUPAC name: 3,7-dimethyl-1-octyl acetate
Molecular formula: C12H24O2
Molecular weight: 200.32 g/mol
Smiles notation: C([C@@H](CCOC(C)=O)C)CCC(C)C
InChl: 1S/C12H24O2/c110(2)65711(3)891412(v4)13/h1011H,59H2,14H3
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 8% in Petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
not irritating
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The given test chemical was considered to be not irritating to humans after 48 hours exposure.
Executive summary:

A skin irritation study was performed by using the given test chemical in humans to assess the irritation potential. Test chemical was tested 8% in petrolatum on human volunteers in a 48 hours closed patch test. No indication of irritation was observed. Hence, the given test chemical was considered to be not irritating to humans after 48 hours exposure.