Fatty acids, C16-18 (even numbered) and C18-unsatd., branched and linear, di- and triesters with trimethylolpropane

Dissociation constant

Link to relevant study record(s)

Reference

Endpoint:

dissociation constant

Type of information:

other: Guideline based expert statement

Adequacy of study:

key study

Study period:

1997-07-09

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

the different methods of OECD Guideline 112 are not applicable due to different points (see below), so only an expert statement is possible

Qualifier:

according to guideline

Guideline:

OECD Guideline 112 (Dissociation Constants in Water)

Principles of method if other than guideline:

The titration method is not applicable since the test substance does not dissolve in water (water solubility < 1 mg/L determined during NOTOX project 205987).
The spectrophotometric method is not applicable since the test substance does not have a chromophoric group.
According to the sponsor the test substance is a trimethylolpropane ester of mainly C16-18 saturated and C18-unsaturated straight and branched chain monocarboxylic acids. However, the structure of the different esters present in the test substance is not known, making the calculation method inapplicable.

GLP compliance:

yes

Dissociating properties:

no

Dissosciation constant: not possible to be determined. However it is expected that esters do not dissociate because they have no ionisable groups

Description of key information

There is no dissociation expected.

Additional information

The dissociation of the substance fatty acids, C16-18 (even numbered) and C18-unsatd., branched and linear, di- and triesters with trimethylolpropane (former CAS 85005 -23 -8) was excluded due to the structure of possible components. The substance has no ionisable groups.