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EC number: 500-202-3 | CAS number: 68308-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- LC / GPC
- Principles of method if other than guideline:
- OECD 107 states that measurements should be made on ionisable substances only in their non-ionized form (free acid or free base) produced by the use of an
appropriate buffer with a pH of at least one unit below (free acid) or above (free base) the pKa. ln this instance, as the test substance is a polymeric mixture, the work was performed at the natural pH of the test substance. - GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Castor oil, oligomeric reaction products with maleic anhydride
- EC Number:
- 500-202-3
- EC Name:
- Castor oil, oligomeric reaction products with maleic anhydride
- Cas Number:
- 68308-83-8
- Molecular formula:
- n.a (UVCB)
- IUPAC Name:
- Castor oil, oligomeric reaction products with maleic anhydride
- Test material form:
- liquid: viscous
Constituent 1
Study design
- Analytical method:
- liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 1.96
- Temp.:
- 25 °C
- Remarks on result:
- other: measured at given pH of the substance
Applicant's summary and conclusion
- Conclusions:
- The test substance, was detected in all noctanol solutions. Test substance was measured in one (Test 1A) of the water solutions, with no substance detected visually in the other water solutions. From comparison of Test 1A and the pre-saturated water blank, a rising baseline was observed in the blank and there was an indication that there was test substance present but this is not conclusive.
As the reported concentration of Test 1A is 37mg/L and the LOD of the method is 40mg/L, it was decided that all the water test solutions should be assigned as <40mg/L. There would be no considerable impact to the result (Log P mean).
The LOD of the method was based on the lowest standard concentration of 0.02mg/ml (20mg/L). As the water layers were diluted 1:1 with the mobile phase before analysis, this becomes 40 mg/L (reported as <40mg/L). Based on the raw data, the LOD of the method is confirmed as approximately <40mg/L. As the LOD is a "less than" value, the Log P is reported as a > value (>1.96) as the actual concentration of substance in test solution is lower than the assigned value.
The LOD value is based on the lowest Iimit of the developed method to give a more accurate Log P value. A more sensitive method could be developed but given the nature of the test substance this would be very difficult. - Executive summary:
OECD 107 Guideline states that individual Log P should be within ±0.3 units of the mean.
The values calculated are between ±0.42, due to the use of LOD values giving greater
variance but this is not regarded as a significant difference and the reported log mean P of
>1.96 is appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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