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Diss Factsheets

Physical & Chemical properties

Vapour pressure

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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-04-13 to 2010-04-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Recent GLP and guideline study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-2,5-dimethoxyaniline
EC Number:
228-782-0
EC Name:
4-chloro-2,5-dimethoxyaniline
Cas Number:
6358-64-1
Molecular formula:
C8H10ClNO2
IUPAC Name:
4-chloro-2,5-dimethoxyaniline

Results and discussion

Vapour pressure
Temp.:
20 °C
Vapour pressure:
0.004 Pa

Any other information on results incl. tables

Table 1             Results of the isothermal TGA analysis

Temperature
(°C)

Weight loss
(µg/min)

VT

(g/cm2/h)

log VT

80

3.00

3.58x1 0-4

-3.45

 

3.18

3.79x10-4

-3.42

90

7.44

8.88x10-4

-3.05

 

8.14

9.71x10-4

-3.01

100

19.2

2.30x10-3

-2.64

 

22.4

2.67x10-3

-2.57

110

42.2

5.04x10-3

-2.30

 

48.8

5.83x10-3

-2.23

Applicant's summary and conclusion

Conclusions:
The isothermal thermogravimetric effusion method was chosen for the determination of the vapour pressure of 4-chloro-2,5-dimethoxyaniline. The vapour pressure of the test substance at 20°C (293K) was 3.65 x 10-3 Pa = 2.74 x 10-5 mm Hg.
Executive summary:

The isothermal thermogravimetric effusion method was chosen for the determination of thevapour pressure of 4-chloro-2,5-dimethoxyaniline. The vapour pressure of the test substance at20°C (293K) was 3.65x10-3Pa = 2.74x10-5mm Hg.