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EC number: 240-299-7 | CAS number: 16143-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation
The dermal irritation potential of target chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) was assessedin various experimental studies which were conducted on rabbits and humans for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substancesBenzyl cinnamate (CAS No: 103-41-3)andBenzyl butyl phthalate (CAS No: 85-68-7). The predicted data usingQSAR toolboxhas also been compared with the experimental data.Based on the available data for the target and read across substances and applying the weight of evidence approach, it can be concluded that chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) is unable to cause skin irritation and thus considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Eye irritation
An ocular irritation potential of target chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) was assessedin various experimental studies which were conducted on rabbits for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substancesBenzyl butyl phthalate (CAS No: 85-68-7). The predicted data usingQSAR toolboxhas also been compared with the experimental data.Based on the available data for the target and read across substances and applying the weight of evidence approach, it can be concluded that chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O’)ferrate(1-) (CAS No: 16143-80-9) is unable to cause eye damage and thus can be considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Reports of the Scientific Committee on Cosmetology (seventh series)
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : Sodium tris (1, 2-naphthoquinone 1-oximato-O, O’) ferrate (1- )
- Molecular formula : C30H18FeN3O6.Na
- Molecular weight : 595.3222 g/mol
- Smiles notation : [Na+].[Fe+2].[O]\N=C\1/C(=O)C=Cc2ccccc12.[O]\N=C\3/C(=O)C=Cc4ccccc34.[O]\N=C\5/C(=O)C=Cc6ccccc56
- InChl : HWLCXJRHGUPXJZ-ZHJLFMMCSA-K
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Preparation of test site:
- other: Intact or abraded skin
- Vehicle:
- other: Aqueous Suspension
- Controls:
- not specified
- Amount / concentration applied:
- Amount : 500mg
Concentration applied: 50% - Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed in treated animals.
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to be not irritating to the skin of rabbit.
- Executive summary:
The skin irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
About 500 mg of 50% aqueous suspension of Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) was applied on intact or abraded skin of each rabbit and then observed for skin reactions.
None of the treated rabbits showed positive reaction. Hence Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to be not irritating to the skin of rabbit.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Reports of the Scientific Committee on Cosmetology (seventh series)
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Eye irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : Sodium tris (1, 2-naphthoquinone 1-oximato-O, O’) ferrate (1- )
- Molecular formula : C30H18FeN3O6.Na
- Molecular weight : 595.3222 g/mol
- Smiles notation : [Na+].[Fe+2].[O]\N=C\1/C(=O)C=Cc2ccccc12.[O]\N=C\3/C(=O)C=Cc4ccccc34.[O]\N=C\5/C(=O)C=Cc6ccccc56
- InChl : HWLCXJRHGUPXJZ-ZHJLFMMCSA-K
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Amount : 100mg
Concentration applied: 100% - Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed in treated animals.
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to be not irritating to the eyes of rabbit.
- Executive summary:
Eye irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
About 100 mg of undiluted Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) was placed into one of the eye of each rabbits and observed for ocular lesions.
Since the chemical failed to induce any ocular reactions, Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to benotirritating to the eyes of rabbit.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Various studieshas been investigated for the test chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits and guinea pigs for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substances Benzyl cinnamate (CAS No: 103-41-3)andBenzyl butyl phthalate (CAS No: 85-68-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
The COMMISSION OF THEEUROPEAN COMMUNITIES reported skin irritation study for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) in rabbits. When 500 mg of 50% aqueous suspension or 500mg (0.5g) of undiluted Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) was applied on intact or abraded skin of each rabbit, none of the treated rabbits showed positive skin reaction. Hence Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to benotirritating to the skin of rabbit.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9).The test Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) is estimated to be not irritating to skin of New Zealand White Rabbits.
The Primary Skin irritation study was conducted by D.L.J. Opdyke (Food and Cosmetics Toxicology 1979, Pages 132–133) for read across chemical Benzyl cinnamate (CAS No: 103-41-3) on 25 human subjects that supported the abov mentioned results for target chemical. Each subject was treated with 8% of Benzyl cinnamate (CAS No: 103-41-3) in petrolatum dermally for 48 hours under a closed path patch.Since no known signs of irritation was observed, the chemicalBenzyl cinnamate (CAS No: 103-41-3)was considered to be not irritating to theskin of human subjects.
The above results were supported by dermal irritation study conducted by Cosmetics Ingredient Review Panel (International Journal of Toxicology,Vol 11, Issue 1, pp. 1 – 23, 1992) of read across chemical Benzyl butyl phthalate (CAS No: 85-68-7) in 6 New Zealand White rabbits. Undiluted Benzyl Butyl Phthlate, 0.5 ml, was applied to the intact and abraded skin of rabbits and effects were observed for 24 h. There was practically no irritation to the rabbit skin exposed to Benzyl butyl phthalate for 24 h. Hence, Benzyl butyl phthalate can be considered as not irritating to New Zealand White rabbit skin.
Based on the available data for thetarget chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substances Benzyl cinnamate (CAS No: 103-41-3)andBenzyl butyl phthalate (CAS No: 85-68-7),it can be concluded thatchemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) is unable to cause skin irritation and considered as not irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Eye irritation:
In different studies,the test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9)has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substanceBenzyl butyl phthalate (CAS No: 85-68-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
The COMMISSION OF THEEUROPEAN COMMUNITIES reported an eye irritation study for target chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) in rabbits. When 0.1 mL of 33% suspension in saline, or 100mg (0.1g) of undiluted Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) was installed into one of the eye of each rabbit, the animals did not produce any ocular lesions. Hence Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to benotirritating to the eyes of rabbit.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated for test chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9).The test Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) is estimated to be not irritating to the eye of rabbits.
The above results were supported by an eye irritation study conducted by Cosmetics Ingredient Review Panel (International Journal of Toxicology,Vol 11, Issue 1, pp. 1 – 23, 1992) for read across chemical Benzyl butyl phthalate (CAS No: 85-68-7).The ocular irritation potential ofBenzyl butyl phthalate was evaluated in 6 New Zealand White rabbits.0.1ml of undiluted Benzyl butyl phthalate was instilled into the conjunctival sac of the eyes of the 6 rabbits and effects were observed till 48 hours.Under the conditions of the study, benzyl butyl phthalate showed slight irritation in rabbit eyes which subsided completely before 48 hours.Hence, Benzyl butyl phthalate can be considered as not irritating to New Zealand White rabbit eyes.
Based on the available data for thetarget chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) and its closely related read across substances Benzyl butyl phthalate (CAS No: 85-68-7),it can be concluded thatchemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) is unable to cause eye irritation and considered as not irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Justification for classification or non-classification
The skin and eye irritation potential of test chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) and its closely relatedread across substances were observed in various studies. The results obtained from these studies indicates that the chemicalSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) is not likely to cause skin and eye irritation. HenceSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) can be classified under the category “Not Classified” for skin and eye as per CLP.
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