Iron manganese trioxide

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: as reported in source record

Justification for type of information:

see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: as reported in source record

Description of key information

Applying read-across to nanosizediron(hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), nanosized iron manganese trioxide is not considered acutely toxic to aquatic invertebrates. Fornano-alphairon hydroxide oxide yellow, the observed 48-h EC50 value for the immobilization of Daphnia magna is > 100 mg/L, a concentration that is 100-fold above the corresponding OECD test limit.

Additional information

Acute toxicity of iron(hydr)oxidenanoforms to aquatic invertebrates was investigated in a reliable study withnano-alphairon hydroxide oxide yellow according to OECD 202 (Neuhahn, 2008). Toxic effects to Daphnia magna were not observed at a limit test concentration of 100 mg/L, representing the respective OECD test limit for acute toxicity, under static conditions and an unbounded 48 h EC 50 value of > 100 mg/L (nominal) was derived.

Based on read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), available data indicate a low potential for acute toxicity ofnanosized iron manganese trioxideto aquatic invertebrates (see table below).

 

Table: Acute toxicity of nanosized iron (hydr)oxides to aquatic invertebrates.

Endpoint	Test species	Test results	Test material/form	Reliability: Reference
Short-term toxicity to aquatic invertebrates	Daphnia magna	EC50 (48h): > 100 mg/L nominal	iron hydroxide oxide yellow / nano, alpha	RL2:Neuhahn, 2008

Supportive information microsized iron (hydr)oxides

For microsized iron (hydr)oxides, the observed 48-h EC50 values for the immobilization of Daphnia magna range from > 100 mg/L to > 10,000 mg/L, a concentration that is 100-fold above the corresponding OECD test limit.