Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-236-8 | CAS number: 28804-46-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The physical state of test item was solid. The test item was milled with the help of air jet milling machine but it chocked up the milling machine (test item converted into the lumps and become solid). Hence, milling of test item was not possible through air jet milling.
Test item was tried to grind with mixer grinder and powder was formed. So, pre-test was conducted without rats for generation of dust using dust generator (Rotating Brush Generator), 70 psi air pressure, brush speed at 600 Rotation per Minute (RPM) and feeding rate set at 20 mm/h. The test item started
to melt, therefore generation of dust was not possible from the test item.
Afterward solubility test was performed with RO water, dimethyl sulphoxide (DMSO) and polyethylene glycol 400. The test item found insoluble in all above listed solvent/vehicle.
Due to above mentioned nature of test item, it is not possible to conduct inhalation study.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
