Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-141-4 | CAS number: 556-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = 1591 mg/kg bw, (rat, similar to OECD Guideline 401, BASFXX/24)
Acute dermal toxicity: LD50 > 4000 mg/kg bw (rat, similar to OECD Guideline 402, BASFXX/24)
Key value for chemical safety assessment
Additional information
There are valid in vivo data available for the assessment of the oral, inhalative and dermal acute toxicity potential of
3-methylbut-2-en-1-ol.
Oral
In the key study, an acute toxicity study similar to OECD Guideline 401 (BASFXX/24), doses of 172, 1376, 1720, 2150, 2752 and 5504 mg/kg body weight of the test substance 3-methylbut-2-en-1-ol were administered by gavage to 10 rats per sex and dose. The animals were observed for a post-dosing period of 7 days for lethality and clinical signs of intoxication. The symptoms reported were described as staggering, dyspnea, restlessness (172 mg/kg bw or higher), apathy, abdominal position, reddened eyes and ears (1376 mg/kg bw or higher), lateral and partly dorsal positions, secretion out of eyes and mouth (1720 mg/kg bw or higher).
The acute oral LD50 of 3 -methylbut-2 -en-1 -ol for male and female rats was determined to be 1591 mg/kg body weight.
In a additional study reported from secondary source (Moreno 1977), an acute oral toxicity study was reported. Doses of 0.34, 0.67, 1.31, 2.56 and 5 g/kg body weight were orally administered to 10 rats per dose. Toxic signs were lethargy, flaccid, ataxia, ptosis and piloerection and lethargy.
The acute oral LD50 of 3-methylbut-2-en-1-ol was reported as 810 mg/kg body weight for rats.
Inhalation
No key study is available for acute inhalative toxicity.
In an Inhalation Risk Test, which used a highly enriched/saturated vapor exposure system at 20°C, 6 rats and 3 rats per sex were exposed to a vapor of 3-methylbut-2-en-1-ol at a concentration of 10.25 and 8.4 mg/l for 3 and 8 hours, respectively (BASFXX/24). One of 6 animals out of the 8 hour exposed rats died within the first 24 hrs after the exposure. Clinical symptoms were attempts to escape, strong secretion out of eyes and nose, and tremors after exposure. No mortality was observed after 3 hours of exposure.
Dermal
In the key study, an acute dermal toxicity in rats (BASFXX/24) similar to OECD Guideline 402, a single dermal administration of the test substance 3-methylbut-2-en-1-ol was performed under occlusive conditions by applying doses of 2000 and 4000 mg/kg body weight of the undiluted test substance for 24 hours (3 animals per sex and group). At the end of the exposure period the residual test substance was rinsed and dried. The observation period following administration was 14 days.
No mortality occurred. The clinical symptoms noted were slight apathy, irregular breathing, and slight local skin irritation which were reversible during the post observation period.
The LD50 for dermal exposure of 3-methylbut-2-en-1-ol in female and male rats is higher than 4000 mg/kg body weight.
In a supportive study reported from secondary source (Moreno 1977), doses of 1.25, 2.5 and 5 g/kg body weight were dermally administered to 4 rabbits per dose. In the high dose group (5 g/kg body weight) 3 of 4 animals died. Toxic sign was ataxia in the mid and high dosed animals.
The LD50 for dermal exposure of 3-methylbut-2-en-1-ol was reported to be 3900 mg/kg body weight for rabbits.
Conclusion
In animal studies, 3-methylbut-2-en-1-ol showed moderate toxicity after single oral uptake and low toxicity after single dermal application. In the Inhalation-risk test (IRT), mortality within 8 hours was observed. Therefore, inhalation of a highly saturated vapor-air mixture may represent a hazard.
Justification for classification or non-classification
Based on the oral LD50 of 1591 mg/kg body weight for rats, 3 -methylbut-2 -en-1 -ol has to be classified according to EU Annex VI of directive 67/548/EEC (R22: Harmful if swallowed) and according to 1272/2008/EEC (Cat. 4) classification for the oral route.
Based on the dermal LD50 of 3900 mg/kg body weight for rabbits, 3 -methylbut-2 -en-1-ol has not to be classified according to EU Annex VI of directive 67/548/EEC and 1272/2008/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.