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EC number: 944-610-3 | CAS number: 286472-48-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: OECD TG 423: LD50 > 2000 mg/kg bw
Acute dermal toxicity: OECD TG 402: LD50 > 2000 mg/kg bw
Acute inhalation toxicity: OECD 403: LC50 > 5.05 g/m3
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 020 mg/m³
- Quality of whole database:
- The acute inhalation toxicity result is of sufficient quality and adequate for this dossier.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The acute dermal toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Acute oral toxicity:
The study was performed according to OECD tg nO. 423 in Wistar strain rat.
A group of three fasted females was treated with the test item at a dose level of 300 mg/kg body weight. Based on the results from this dose level, further groups of fasted females were treated at a dose level of 2000 mg/kg body weight. Dosing was performed sequentially.
The test item was administered orally undiluted at a dose level of 2000 mg/kg body weight and as a solution in arachis oil BP at a dose level of 300 mg/kg body weight.
There were no deaths and clinical observations included hunched posture that was noted 4 hours after dosing in one animal treated at a dose level of 2000 mg/kg. There were no other signs of systemic toxicity noted. All animals showed expected gains in body weight. No abnormalities were noted at necropsy.
The acute oral median lethal dose (LD50) of the test item in the female Wistar strain rat was estimated to be greater than 2000 mg/kg body weight
Acute dermal toxicity:
In this study (conducted to OECD TG No.402), 10 rats (5 males and 5 females) were administered (single, 24 hour, semi-occluded dermal application) the substance at a dose level of 2000 mg/kg bw.
The rats showed no mortality, no clinical signs, no signs of dermal irritaiton, expected gains in body weight, no abnormalities at necropsy.
The acute dermal LD50 for the substance in male and female rats was determined to be greater than 2000 mg/kg bw.
Acute inhalation toxicity:
The study was performed to assess the acute inhalation toxicity of the test item, according to OECD TG No. 403 “Acute Inhalation Toxicity” and with Method B.2. Acute Inhalation Toxicity, 2014, of Commission Regulation (EC) No. 440/2008.
No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 5.05 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 hour LC50) of the test item in the Wistar strain rat was greater than 5.05 mg/L.
Justification for classification or non-classification
According to the criteria outlined in Annex I of Regulation (EC) No 1272/2008/EC (CLP), the substance does not have to be classified for acute toxicity by the oral, dermal and inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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