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Diss Factsheets
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EC number: 261-629-6 | CAS number: 59151-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The study was performed on a similar substance to the registered substance and as such is considered to be sufficient to address the endpoint by read-across.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test substance is applied to one eye of each of a group of rabbits (2 rabbits) by gently pulling the lower eyelid away from the eyeball and placing 10 microL in the sac so formed. Treated eyes are examined 24 hours after treatment and thereafter at specified daily intervals and are graded for corneal, conjunctival and irridial damage. Corneal thickness is also measured and corneal swelling is recorded if present.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl 3-oxo-2-pentylcyclopentaneacetate
- EC Number:
- 246-495-9
- EC Name:
- Methyl 3-oxo-2-pentylcyclopentaneacetate
- Cas Number:
- 24851-98-7
- Molecular formula:
- C13H22O3
- IUPAC Name:
- Methyl 3-oxo-2-pentyl-1-cyclopentaneacetate
Constituent 1
- Specific details on test material used for the study:
- Test material name (as stated in the report): Methyl Dihydrojasmonate (S15102-T01)
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age: 8 weeks old
Weight: At least 1 Kg
with no spontaneous eyes lesions
The animals are housed individually in cages with wire-mesh floors and hace access to a certified pelleted commercial rabbit diet and tap water ad libitium.
Test system
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Group B_ undiluted (as supplied)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 10 microL (100% concentration)
- Duration of treatment / exposure:
- instillation
- Observation period (in vivo):
- 1, 2, 3, 4, 7, 9, 11, 14, 16, 18 and 21 days
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1291 and 1292
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: 1291 and 1292
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: 1291 and 1292
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1291 and 1292
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Both eyes showed only a transient slight erythema of the conjunctivae. The corneas of both eyes were unaffected by the treament and remained entirely normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this test, Methyl Dihydrojasmonate (S15102-T01) does not show irritant effect to eyes, it does not met the criteria for Eye irritation classication according the CLP Regulation (EC) No. 1272/2008.
- Executive summary:
Methyl Dihydrojasmonate is tested to demonstrate the eye irritation potential. Test substance is applied to one eye of each of a group of rabbits (2 rabbits) by gently pulling the lower eyelid away from the eyeball and placing 10 microL in the sac so formed. Treated eyes are examined 24 hours after treatment and thereafter at specified daily intervals and are graded for corneal, conjunctival and irridial damage. Both eyes showed only a transient slight erythema of the conjunctivae. The corneas of both eyes were unaffected by the treament and remained entirely normal.
Under the conditions of this test, Methyl Dihydrojasmonate (S15102-T01) does not show irritant effect to eyes, it does not met the criteria for classication according the CLP Regulation (EC) No. 1272/2008.
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