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Diss Factsheets
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EC number: 700-834-1 | CAS number: 9041-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited study summary. Not GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The effects on central nervous system of a new low molecular weight test substance (OP/LMWH) were studied in mice and rats. The effect of OP/LMWH on respiration, blood pressure and heart rate was studied in guinea-pigs and rats.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- nonasodium 2-({6-[(2-carboxylato-4-hydroxy-6-{[6-hydroxy-5-(sulfonatoamino)-4-(sulfonatooxy)-2-[(sulfonatooxy)methyl]oxan-3-yl]oxy}-5-(sulfonatooxy)oxan-3-yl)oxy]-4-hydroxy-5-(sulfonatoamino)-2-[(sulfonatooxy)methyl]oxan-3-yl}oxy)-4-hydroxy-3-(sulfonatooxy)-3,4-dihydro-2H-pyran-6-carboxylate
- EC Number:
- 700-834-1
- Cas Number:
- 9041-08-1
- Molecular formula:
- not applicable (UVCB substance)
- IUPAC Name:
- nonasodium 2-({6-[(2-carboxylato-4-hydroxy-6-{[6-hydroxy-5-(sulfonatoamino)-4-(sulfonatooxy)-2-[(sulfonatooxy)methyl]oxan-3-yl]oxy}-5-(sulfonatooxy)oxan-3-yl)oxy]-4-hydroxy-5-(sulfonatoamino)-2-[(sulfonatooxy)methyl]oxan-3-yl}oxy)-4-hydroxy-3-(sulfonatooxy)-3,4-dihydro-2H-pyran-6-carboxylate
- Details on test material:
- Batch No.: 21-23
Purity: not specified
Constituent 1
Test animals
- Species:
- other: mice, rats and guinea-pigs
- Strain:
- other: Swiss strain mice, Sprague-Dawley strain rats, guinea-pigs not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Mice weighing 18-20 g, rats weighing 230-280 g, guinea-pigs weighing 450-500 g.
- Housing: Housed in Makrolon cages
- Diet (e.g. ad libitum):Pelleted dry diet Altromin-R, Altromin-CL were available ad libitum.
- Water (e.g. ad libitum): Tap water was available ad libitum.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23°C
- Humidity (%): 55-60%
- Air changes (per hr): 12 times/h
- Photoperiod (hrs dark / hrs light): 12:12 light/dark
No additional data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
Results and discussion
- Details on results:
- 1. Effect on general behaviour
The test substance, administered by intravenous route, did not cause any behavioural changes up to 1000 mg/kg in mice. At 1000 mg/kg, decrease of awareness and mood was observed.
2. Effect on spontaneous movement
The test substance at 2 and 10 mg/kg s.c. showed no effect on spontaneous movement of mice.
3. Effect on motor coordination
The test substance had no effect no motor coordination at 2 and 10 mg/kg s.c.
4. Anti-reserpine activity
The test substance at 2 and 10 mg/kg/s.c. did not show any antireserpine activity.
5. Effect on yohimbine-induced toxicity
The test substance at 10 mg/kg s.c. slightly increased the toxicity induced by yohimbine in mice.
6. Effect on apomorphine-induced stereotyped behaviour
The test substance, at 2 and 10 mg/kg s.c., showed no effect on apomorphine-induced stereotypy in rats.
7. Anticonvulsivant activity
The test substance, at 2 and 10 mg/kg s.c., did not inhibit electroshock-induced, pentetrazol-induced and strychnine-induced convulsions in mice.
8. Effect on pentobarbital-induced hypnosis
The test substance did not significantly prolong the sleeping time at 2, 5 and 10 mg/kg s.c.
9. Analgesic effect
The test substance up to 10 mg/kg s.c. did not exert any analgesic effect in the rat.
10. Anti-oxotremorine activity
The test substance at 2 and 10 mg/kg s.c. did not antagonize hypothermia and peripheral phenomena induced by oxotremorine.
11. Effect on blood pressure and heart rate
The test substance did not increase the blood pressure and heart rate in the rat up to 10 mg/kg i.v.
12. Effect on respiration
The test substance did not change the respiration rate of guinea-pigs up to 10 mg/kg i.v.
Applicant's summary and conclusion
- Conclusions:
- The test substance, up to 10 mg/kg/s.c., did not show any effect on central nervous system and did not increase the blood pressure, heart rate and respiration rate up to 10 mg/kg i.v.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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