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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From May 17, 2016 to June 8, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
other: A.24. partition coefficient n-octanol/water
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.2
Remarks on result:
other: at room temperature

Results (details):

Since the calculation of the partition coefficient log Pow (program KOWWIN (part of EPI Suite)) was established to be 6.23, the partition coefficient n-octanol/water of the test substance at room temperature was determined by the HPLC method.

Conclusions:
Under the study conditions, the log Pow of the test substance was determined to be 5.2 (at room temperature).
Executive summary:

A study was conducted to determine the n-octanol/water partition coefficient of the test substance according to OECD Guideline 117 and EU Method A.24. The HPLC method was used. This method is based on the correlation between the retention of a substance on a reversed phase column and the n-octanol/water partition coefficient Pow (which is estimated by the ratio between the saturation concentrations of the test substance in n-octanol and water). The experiments were done in duplicates. Under the study conditions, the log Pow was determined to be 5.2 (at room temperature) (Dornhagen, 2016).

Description of key information

The partition coefficient was determined according to OECD Guideline 117 and EU Method A.24 (HPLC method) (Dornhagen, 2016).

Key value for chemical safety assessment

Log Kow (Log Pow):
5.2

Additional information