Registration Dossier
Registration Dossier
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EC number: 243-325-5 | CAS number: 19800-42-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 17, 2016 to June 8, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: A.24. partition coefficient n-octanol/water
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.2
- Remarks on result:
- other: at room temperature
- Conclusions:
- Under the study conditions, the log Pow of the test substance was determined to be 5.2 (at room temperature).
- Executive summary:
A study was conducted to determine the n-octanol/water partition coefficient of the test substance according to OECD Guideline 117 and EU Method A.24. The HPLC method was used. This method is based on the correlation between the retention of a substance on a reversed phase column and the n-octanol/water partition coefficient Pow (which is estimated by the ratio between the saturation concentrations of the test substance in n-octanol and water). The experiments were done in duplicates. Under the study conditions, the log Pow was determined to be 5.2 (at room temperature) (Dornhagen, 2016).
Reference
Results (details):
Since the calculation of the partition coefficient log Pow (program KOWWIN (part of EPI Suite)) was established to be 6.23, the partition coefficient n-octanol/water of the test substance at room temperature was determined by the HPLC method.
Description of key information
The partition coefficient was determined according to OECD Guideline 117 and EU Method A.24 (HPLC method) (Dornhagen, 2016).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.2
Additional information
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