Reaction mass of (3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal and (3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01 September - 07 December 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study conducted in accorance with international guidelines and in accordance with GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

OECD harmonised ring method

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Assumed stable. Stability at higher temperatures not availbale.
- Solubility and stability of the test substance in the solvent/vehicle: N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

Key result

Surface tension:

57.9 mN/m

Temp.:

20 °C

Conc.:

90 other: % of test item saturation

Table 2       Surface Tension of the Test Item

Measurement	Time passed after transfer test solution to test vessel [minutes]	Surface tension [mN/m]
		individual	mean^1	mean multiplied by Φband Harkins-Jordan corrected value
1	17	61.7	59.5	57.9
2	18	59.0
3	19	59.3
4	20	59.4
5	21	59.6
6	22	59.5
7	23	59.6

¹mean calculated from measurements 3 - 7, after equilibration was reached.

Conclusions:

The surface tension of a test solution at 90 % of the test item saturation solubility in water was 57.9 mN/m at 20 ºC.

Executive summary:

The surface tension of the test substance was determined using the OECD harmonised ring method in accordance with EU Method A.5 and OECD 115 (1995).

The surface tension of a test solution at 90 % of the test item saturation solubility in water was 57.9 mN/m at 20 ºC.

 

Description of key information

Surface Tension: 57.9 mN/m at 20 ºC, EU Method A.5 - OECD harmonised ring method, Anon, 2017.

Key value for chemical safety assessment

Surface tension:

57.9

Additional information

The surface tension of the test substance was determined using the OECD harmonised ring method in accordance with EU Method A.5 and OECD 115 (1995). The surface tension of a test solution at 90 % of the test item saturation solubility in water was 57.9 mN/m at 20 ºC.

 

Refer to Section 4.8 of IUCLID. The critical micelle concentration assay was conducted in response to the surface tension measurement as a surrogate for water solubility, the surface tension measurement of 57.9 mN/m indicated that the substance was borderline surface-active. As no critical micelle concentration could be determined, it was concluded that the substance does not behave like a surfactant, and the low surface tension measurement was potentially an artefact of surface active impurities (trace carboxylic acid or an alkoxy- equivalent) with a higher water solubility than the test item, causing a false positive in the OECD 115 surface tension measurement at 90 % saturation.

 

It was concluded that the substance is not surface-active.