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EC number: 243-349-6 | CAS number: 19819-98-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Remarks:
- ErC50 at 96h
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR
- Justification for type of information:
- Executive summary: The 72h acute algae ErC50 for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 39.47 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h ErC50(mg/L) = MW x 10^ (-0.6922 Log Kow + 0.9253). Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 6.4); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l. The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record, further supports this prediction.
- Guideline:
- other: REACH Guidance R.6: QSARs and grouping of chemicals. Version May 2008.
- GLP compliance:
- no
- Test organisms (species):
- other: green algae
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Key result
- Dose descriptor:
- EC50
- Effect conc.:
- 39.47 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: ECOSAR class: Neutral organics
- Details on results:
- The ErC50 is 39.47 mg/L
- Validity criteria fulfilled:
- yes
- Remarks:
- The substance is in the applicability domain of the model.
- Conclusions:
- The 96h-ErC50 is 39.47 mg/L.
- Executive summary:
Executive summary: The 72h acute algae ErC50 for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 39.47 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h ErC50(mg/L) = MW x 10^ (-0.6922 Log Kow + 0.9253). Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 6.4); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l. The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record, further supports this prediction.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Remarks:
- EC10/NOEC
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Rel 2 is assigned because of the method being a QSAR
- Justification for type of information:
- Executive summary: The chronic algae ChV for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 10.58 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h-ChV(mg/L) = MW x 10^ (-0.6029 Log Kow + 0.1648).
Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 8.0); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l.
The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for chronic algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record further supports this prediction. - Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance R.6
- Test organisms (species):
- other: Green algae
- Water media type:
- freshwater
- Key result
- Dose descriptor:
- EC10
- Effect conc.:
- 10.58 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: EC10 is based on the equivalent ChV (chronic value in ECOSAR)
- Validity criteria fulfilled:
- yes
- Remarks:
- The substance is in the applicability domain of the model.
- Conclusions:
- The EC10/NOEC is 10.58 mg/L
- Executive summary:
Executive summary: The chronic algae ChV for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 10.58 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h-ChV(mg/L) = MW x 10^ (-0.6029 Log Kow + 0.1648).
Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 8.0); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l.
The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for chronic algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record further supports this prediction.
Referenceopen allclose all
Description of key information
The 96h acute algae ErC50 for the neutral organic substance Peomosa is predicted to be 39.47 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11,a molecular weight (MW) of 136.19 and the equation: 96h ErC50(mg/L) = MW x 10^(-0.6922 Log Kow + 0.9253).
The chronic algae ErC10 for the neutral organic substance Peomosa is predicted to be 10.58 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11,a molecular weight (MW) of 136.19 and the equation: 96h-ChV(mg/L) = MW x 10^ (-0.6029 Log Kow + 0.1648).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 39.47 mg/L
- EC10 or NOEC for freshwater algae:
- 10.58 mg/L
Additional information
The 72h acute algae ErC50 for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 39.47 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h ErC50(mg/L) = MW x 10^ (-0.6922 Log Kow + 0.9253). Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 6.4); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l. The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record, further supports this prediction.
The chronic algae ChV for the neutral organic substance Peomosa (2-(2-methylphenyl)ethanol) is predicted to be 10.58 mg/L based on the ECOSAR SAR for neutral organics using a partition coefficient (Log Kow) of 2.11, a molecular weight (MW) of 136.19 and the equation: 96h-ChV(mg/L) = MW x 10^ (-0.6029 Log Kow + 0.1648).
Peomosa is in the applicability domain of the ECOSAR prediction because: a) Peomosa is a neutral organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this neutral organic); b) its predicted Log Kow is 2.11 (measured 2.1) (=< 8.0); c) its MW is 136.19 (< 1000); and d) the toxicity predicted is below its water solubility which is 12339 mg/l.
The fit in the applicability domain and the availability of an analogue in the training set results in limited uncertainty of the Peomosa prediction. This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for chronic algae toxicity on neutral organics (see attached report). The adequate and reliable documentation, presented in the attached file in the study record further supports this prediction.
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