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Diss Factsheets
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EC number: 944-572-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment supported with ToxRTool (Schneider, K. et al. "ToxRTool", a new tool to assess the reliability of toxicological data. Toxicol Lett. 2009 Sep 10:189(2):138-44)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.3
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
- EC Number:
- 944-572-8
- Molecular formula:
- C18H29NO2 - C19H31NO2 (main constituents)
- IUPAC Name:
- 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
- Details on test material:
- - Name of test material (as cited in study report): RD 5893; Dodecylsalicylaldoxime
- Physical state: dark yellow, semi-solid viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.5, 0.89, 1.58, 2.81 and 5.0 g/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 220 mg/kg bw
- 95% CL:
- >= 1 060 - <= 1 410
- Mortality:
- Dose [g/kg] mortality
0.50 0/10
0.89 2/10
1.58 7/10
2.81 10/10
5.00 10/10 - Clinical signs:
- For all concentrations salivation, decreased activity, ataxia, bloody nasal discharge, diarrhoea were observed to a varoius degree
- Body weight:
- Body weight increase of surviving rats was normal.
- Gross pathology:
- Necropsy was performed in all rats that died during the study.
Lungs: pale and mottled
Spleen: pale and in the two highest concentration granular or dark in some rats
Kidney: pale and in the two highest concentration mottled or dark in some rats
Intestine: contains yellow (viscous) liquid; vascularised
Gastrointestinal tract: contains yellow (viscous) liquid; vascularised (higest concentration only)
Liver: dark in a few rats in the two highest concetrations - Other findings:
- none stated
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- With an LD50 of 1220 mg/kg bodyweight, the test substance is considered as acute toxic Category 4.
- Executive summary:
The test substance was assessed for its acute oral toxicity using the OECD 401 protocol. Four dose levels between 0.5 and 5 g/kg bw were applied to SD rats and a control group receiving the vehicle was assigned. 5 male and 5 female animals were assigned to each dose group. The LD50 was determined to be 1220 mg/kg bodyweight using a linear regression model. The test substance is assigned to acute toxic Category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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