Registration Dossier
Registration Dossier
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EC number: 200-164-5 | CAS number: 53-16-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13. July to 14. Aug 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methoxyoestra-1,3,5(10)-trien-17-one
- EC Number:
- 216-613-3
- EC Name:
- 3-methoxyoestra-1,3,5(10)-trien-17-one
- Cas Number:
- 24508-10-9
- Molecular formula:
- C19 H24 O2
- IUPAC Name:
- 3-methoxy-1,3,5(10)-estratriene-17β-ol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- physiological saline
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3/sex
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occurred
- Clinical signs:
- other: The test substance was tolerated without any clinical findings.
- Gross pathology:
- The test substance was tolerated without any macroscopic pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- other: no substance related mortality observed
- Conclusions:
- The acute dermal toxicity of estrone methylether is above 2000 mg/kg body weight.
- Executive summary:
The single dermal, 24 h-administration of the test item to male and female Wistar rats at the dose of 2000 mg/kg was tolerated without any clinical or macroscopic pathological findings. The acute dermal toxicity of the test item is above 2000 mg/kg body weight.
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