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Diss Factsheets
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EC number: 432-240-0 | CAS number: 12056-51-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- experimental data made available by ECHA
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ECHA robust summaries for 12056-51-8
- Author:
- ECHA
- Year:
- 2 019
- Bibliographic source:
- ECHA robust summaries for 12056-51-8, ECHA,2019
Materials and methods
- Objective of study:
- other: Assessment of toxicokinetic behaviour
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Assessment of toxicological behavior
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 432-240-0
- EC Name:
- -
- Cas Number:
- 12056-51-8
- Molecular formula:
- K2Ti6O13
- IUPAC Name:
- Potassium hexatitanate
- Test material form:
- solid: fibres
- Details on test material:
- Name of the test chemical: Potassium hexatitanate
Molecular formula: K2Ti6O13
Molecular Weight: 573 g/mol
Substance Type: inorganic
Physical State: Solid
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Acute and sub-chronic inhalation studies and an acute oral toxicity showed no evidence of systemic toxicity. The effects seen in the inhalation studies were attributable to local effects in the lung and upper respiratory tract. Although the molecular weight does not preclude absorption, the substance has very low solubility in water and organic solvents. In view of this low solubility and the toxicity
study results, it is unlikely that any significant systemic absorption of this substance would occur, although transport of sufficently small fibres, by phagocytic cells, into the
lymphatic circulation is a possibility. - Details on distribution in tissues:
- Since it is unlikely that any significant absorption could occur, discussion of distribution, metabolism and excretion is largely irrelevant for this inorganic substance. Fibres entering the lymphatic system would be unlikely to dissolve and become bioavailable due to the very low solubility. These factors may, however, result in biopersistence of fibres deposited in the respiratory tract.
- Details on excretion:
- Since it is unlikely that any significant absorption could occur, discussion of distribution, metabolism and excretion is largely irrelevant for this inorganic substance. Fibres entering the lymphatic system would be unlikely to dissolve and become bioavailable due to the very low solubility. These factors may, however, result in biopersistence of fibres deposited in the respiratory tract.
Any other information on results incl. tables
The test chemical is majorly available in the form of fibre. Its fibrous nature indicates that inhalation exposure would be possible and this is the most relevent route of exposure. The substance is stable so exposure to degradents would not be expected.
Applicant's summary and conclusion
- Conclusions:
- The test chemical is majorly available in the form of fibre. Its fibrous nature indicates that inhalation exposure would be possible and this is the most relevent route of exposure. The substance is stable so exposure to degradents would not be expected.
- Executive summary:
Absorption:
Acute and sub-chronic inhalation studies and an acute oral toxicity showed no evidence of systemic toxicity. The effects seen in the inhalation studies were attributable to local effects in the lung and upper respiratory tract. Although the molecular weight does not preclude absorption, the substance has very low solubility in water and organic solvents. In view of this low solubility and the toxicity study results, it is unlikely that any significant systemic absorption of this substance would occur, although transport of sufficently small fibres, by phagocytic cells, into the lymphatic circulation is a possibility.
Distribution, Metabolism,Excretion
Since it is unlikely that any significant absorption could occur, discussion of distribution, metabolism and excretion is largely irrelevant for this inorganic substance. Fibres entering the lymphatic system would be unlikely to dissolve and become bioavailable due to the very low solubility. These factors may, however, result in biopersistence of fibres deposited in the respiratory tract.
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