Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
3,4 -dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic algae and cyanobacteria.
Key value for chemical safety assessment
Additional information
QSAR Disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 3,4 -dimethoxyphenethylamine (CAS 120 -20 -7) (Q)SAR results were used for toxicity to aquatic organisms.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, experimental studies on aquatic toxicity are not provided.
Assessment
No experimental data are available on the toxicity to aquatic algae for 3,4 -dimethoxyphenethylamine (CAS 120 -20 -7). Therefore, data have been estimated using ECOSAR v1.11 (US EPA, 2012). In addition, a read-across approach to the structurally analogous substances 3,4 -dimethoxyphenylacetonitrile (CAS 93-17-4), 4 -allylveratrole (CAS 93-15-2) was performed.
ECOSAR calculated the algal toxicity based on user-entered values for log Kow, water solubility and melting point. ECOSAR assigned the substance to the chemical class of aliphatic amines. The 96-h EC50 was estimated to be 575 mg/L, the chronic value was 147 mg/L. The substance was within the applicability domain of the model.
A study on growth inhibition of the freshwater algae Rhaphidocelis subcapitata, exposed to the analogue 4 -allylveratrole (CAS 93-15-2) for 72h, was performed according to OECD TG 201. Based on measured test concentrations, the 72-h ErC50 was determined to be 22 mg/L (72-h NOEC = 4.6 mg/L). The data are from a reliable source. Though no test report is available at present the data from this source are known to be well documented and tests are performed according to GLP and OECD guidelines (NITE, J-CHECK database, Japan).
The other source chemical 3,4 -dimethoxyphenylacetonitrile (CAS 93-17-4) was tested according to OECD TG 201 using Desmodesmus subspicatus as test species. Test concentration were analytically verified. Based on nominal test concentrations, the 72-h ErC50 was determined to be greater than 100 mg/L. The 72-h ErC10 was 41.8 mg/L (72-h NOEC = 25 mg/L; BASF AG, 2003; report no. 02/0651/60/1).
Based on the available QSAR data the target substance is with high probability acutely not harmful to aquatic algae; however, based on a weight-of-evidence approach and a worst-case assessment, 3,4 -dimethoxyphenethylamine (CAS 120-20-7) is assessed to be acutely harmful to aquatic algae and cyanobacteria. Chronic effects are not expected (NOEC/EC10 > 1 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.