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EC number: 220-293-0 | CAS number: 2706-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed jornal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Absorption, Metabolism and Excretion of the Sulphonated Azo Dye, Acid Yellow, by Rats
- Author:
- Ronald R. Scheline and Britt Longberg
- Year:
- 1 965
- Bibliographic source:
- Acta pharmacol. el toxicol. 1965, 23, 1-14
- Reference Type:
- secondary source
- Title:
- Information P·roflles on Potential Occupational Hazards: Aminoazobenzenes
- Author:
- National Institute for Occupational Safety and Health
- Year:
- 1 981
- Bibliographic source:
- U.S. DEPARTMENT OF COMMERCE NATIONAL TECHNICAL INFORMATION SERVICE, November 1981, 1-116
Materials and methods
- Objective of study:
- other: Absorption, Metabolism and Excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Absorption, Metabolism and Excretion of Acid Yellow in rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate
- EC Number:
- 220-293-0
- EC Name:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate
- Cas Number:
- 2706-28-7
- Molecular formula:
- C12H11N3O6S2.2Na
- IUPAC Name:
- disodium 2-amino-5-[(4-sulfonatophenyl)diazenyl]benzenesulfonate
- Reference substance name:
- Acid Yellow
- IUPAC Name:
- Acid Yellow
- Details on test material:
- - Name of test material (as cited in study report): Acid Yellow
- Molecular formula (if other than submission substance): C12H11N3O6S2.2Na
- Molecular weight (if other than submission substance): 401.3301 g/mole
- Substance type: Organic
- Physical state: Solid
- Impurities (identity and concentrations): 34 %
Constituent 1
Constituent 2
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 250 to 350 g
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):water , ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 100 mg
- Amount of vehicle (if gavage): 1 ml - Duration and frequency of treatment / exposure:
- 3 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg -oral
2 mg- intraperitoneal
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- not specified
- Positive control reference chemical:
- No data
- Details on study design:
- No data
- Details on dosing and sampling:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary studies:
- No data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Total gastrointestinal absorption was observed in rat by oral route
- Details on distribution in tissues:
- No data
- Details on excretion:
- Only 2.6, 0.0, and 0 .1.2S. of the unchanged compound appeared in the urine, feces, and bile, respeot1vely and 87% intraperitoneal amount found in the urine. prolonged excretion in bile. Total 1.1 % was excreted in urine.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate was metabolite in the form of N-acetylsulphanilic acid and 5-acetylamino- 2-aminobenzene sulphonic acid conjugate respectively.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Acid Yellow was considered to be have Low bio-accumulation potential in rats based on study results. - Executive summary:
Upon oral administration, Acid Yellow were totally absorbed by gastrointestinal trak, metabolite in the form of N-acetylsulphanilic acid and 5-acetylamino- 2-aminobenzene sulphonic acid conjugaterespectively. only 2.6, 0.0, and 0 .1.2S. of the unchanged compound appeared in the urine, feces, and bile, respeot1vely and 87% intraperitoneal amount found in the urine. prolonged excretion in bile. Total 1.1 % was excreted in urine at 24 hours and not identified after 42 hours. Theefore Acid Yellow was considered to be have Low bio-accumulation potential in rats based on study results.
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