Registration Dossier
Registration Dossier
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EC number: 203-909-2 | CAS number: 111-80-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute Oral Study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl non-2-ynoate
- EC Number:
- 203-909-2
- EC Name:
- Methyl non-2-ynoate
- Cas Number:
- 111-80-8
- Molecular formula:
- C10H16O2
- IUPAC Name:
- methyl non-2-ynoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 4
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 2 220 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
An oral LD50 study was conducted on groups of 10 rats per dose, using various doses of the test material. The animals were observed for 14 days for mortality and clinical signs.
C.I. = 1.79 - 2.65 g/kg.
Methyl Octine Carbonate is classified as Category 4 based on the GHS criteria.
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