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EC number: 212-737-7 | CAS number: 865-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-08-02 to 1999-08-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The Corrositex assay is used as a standardized and quantitative in vitro corrosivity test. The test is based on the time that is required for the test sample to pass through a biobarrier membrane and produce a change in the Chemical Detection System (CDS). The Packing Group is determined by the time interval required to break through the biobarrier matrix.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Lithium methanolate
- EC Number:
- 212-737-7
- EC Name:
- Lithium methanolate
- Cas Number:
- 865-34-9
- Molecular formula:
- CH4O.Li
- IUPAC Name:
- lithium methanolate
- Details on test material:
- - Name of test material (as cited in study report): Lithium methoxide in methanol (519-01a)
- Physical description: Pale brown non-viscous liquid
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: Mean breakthrough time
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- other: Mean breakthrough time of 21:05 min was observed.
Any other information on results incl. tables
The results of the Categorization Screen indicated that the test article, lithium methoxide in methanol (519 -01a), fell into category 1. Therefore, it was evaluated using the timetable in Table 1.
The test article was examined in a single trial (four replicates) to determine the packing group and the breakthrough time. Table 3 summarizes the results of the definitive Corrositex assay for the test article and the positive control. A control (color blank) vial was included in the assay only for the purpose of comparison with the test article and positive control. Therefore, no breakthrough results are reported for this vial. The results of the positive control, NaOH (EM Science, lot# 342774499, >97% purity), fell within two standard deviations of the historical mean, thereby meeting the acceptance criteria.
One of the four replicate vials showed a break through at 1:35:00 (elapsed time presented as hr:min:sec) which was much longer than the other three vials. This value was considered an outlier and was not used in the mean break through time calculation.
Table 3: Results of the definitive Corrositex assay
Test article |
Break Through Time (min:sec) |
Packing group |
pH* |
||||
Vial 1 |
Vial 2 |
Vial 3 |
Vial 4 |
Mean |
|||
Lithium methoxide |
22:00 |
20:26 |
20:49 |
01:35:00(a) |
21:05 |
II |
13 |
NaOH |
11:22 |
NA |
NA |
Na |
11:22 |
NA |
NA |
* 100 µL : 1 mL solution in deionized water
NA: Not Applicable
(a): Outlier, not included in the mean break through time calculation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Based on the results of the Corrositex test, the test substance is corrosive.
- Executive summary:
The purpose of this Corrositex Assay was to evaluate the potential corrosivity of the test substance, lithium methoxide in methanol, as measured by its penetration through a calibrated biobarrier into a chemical detection system (CDS). The test article was tested in one definitive assay (four replicates) to measure the mean breakthrough time and determine the Packing Group. Based on the determined breakthrough time, lithium methoxide was assigned to Packing Group II in the Corrositex Assay. Based on the results of the Corrositex test, the substance has to be classified as Category 1 B (corrosive) based on GHS criteria.
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