Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 682-131-9 | CAS number: 1190427-50-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-05-11 to 2016-09-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- not soluble in water, slow decomposition by hydrolysis
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- inoculum concentration: 30 mg dry solid per litre
The treatment plant clarifies predominantly domestic wastewater and has a capacity of 600.000 inhabitant equivalents
Sampling date: 17 May 2016
Dry solid of the activated sludge was determined as 4.95 g/l by weight measurements after drying at 105°C (mean of triplicate measurements). The activated sludge was washed twice with tap water by setting the sludge, decanting the supernatant and re-suspending the sludge - Duration of test (contact time):
- 28 d
- Initial conc.:
- ca. 20 mg/L
- Based on:
- TOC
- Remarks:
- corresponds to 47.6 - 47.8 mg of the test item per test vessel
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to the guideline
- Additional substrate: no
- Test temperature: 22.3-23.6 C
- pH adjusted: no
- suspended solid: 4.95 g/l
- Aeration of dilution water: yes
- Continuous darkness: diffuse light
TEST SYSTEM
- Culturing apparatus: gas wash bottles (200 ml volume) with lateral connecting pieces for butyl rubber septums
- Number of culture flasks/concentration: 3 containing test substance and inoculum; 3 containing inoculum (blanc), 3 containing refernce compound and inoculum, 1 containing test substance and reference substance and inoculum (toxicity control)
- Method used to create aerobic conditions:
- Method used to create anaerobic conditions:
- Measuring equipment:
- Test performed in closed vessels due to significant volatility of test substance:
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used:
- Other:
SAMPLING
- Sampling frequency:
- Sampling method:
- Sterility check if applicable:
- Sample storage before analysis:
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank:
- Abiotic sterile control:
- Toxicity control:
- Other:
STATISTICAL METHODS: - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Remarks on result:
- other: no biodegradation occured during 28 days
- Details on results:
- Test Substance: There was no degradation within 28 days, the degradation extend at the end of the test was slightly negative which is caused by a slightly higher CO2-evolution in the blank than in the test vessel
Reference substance: The reference compound sodium benzoate reached the pass levels for ready biodegradability within 4 days.
Toxicity control: The degradation in the toxicity control after 14 days was 44.7%. According to the guideline criteria OECD 301, the test substance had no toxic effect to the inoculum.
Blank: The mean CO2-evolution of the blank flask was 29.5 mg/l on day 28 after acidification
Before adding the test substance, the IC in the reactor was determined, only insignificant amounts of IC < 5% were found.
The temperature was 22.3-23.6°C throughout the whole study. The aeration rate was in the tolerated range of 1.6-5.5 bubbles/second
The difference of extremes of replicate values at the end of the test and at the end of the 10-d window was less than 20% - Results with reference substance:
- Reference substance: The reference compound sodium benzoate reached the pass levels for ready biodegradability within 4 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The substance is not readily biodegradable under the test condition
- Executive summary:
The substance was tested in a valid CO2 evolution test according to OECD 301 B and under GLP. The substance is not readily biodegradable under the test condition.
Reference
Table 1: Ultimate biodegradation after x days[% of ThCO2]
Reactor |
Day |
0 |
4 |
8 |
11 |
14 |
21 |
28 |
29 |
15 |
Test flask |
0 |
1.0 |
-0.1 |
0.1 |
0.8 |
-0.7 |
-0.9 |
-0.5 |
16 |
|
0 |
0.8 |
0.0 |
0.0 |
0.7 |
-1.5 |
-1.7 |
-1.7 |
17 |
|
0 |
0.1 |
-1.0 |
-1.5 |
-1.5 |
-4.3 |
-5.2 |
-5.0 |
4 |
Reference |
0 |
71.1 |
83.0 |
86.6 |
92.0 |
93.9 |
94.3 |
94.2 |
5 |
flask |
0 |
77.3 |
89.0 |
94.9 |
100.8 |
105.4 |
107.4 |
107.2 |
6 |
|
0 |
74.7 |
86.8 |
87.9 |
92.1 |
96.6 |
98.4 |
98.4 |
|
Toxicity control |
|
|
|
|
|
|
|
|
18 |
test item |
0 |
37.8 |
42.7 |
43.2 |
44.7 |
48.0 |
46.3 |
45.6 |
|
reference item |
|
|
|
|
|
|
|
|
Table 2: Mean CO2 -evolution of blank flasks after x days
Day |
0 |
4 |
8 |
11 |
14 |
21 |
28 |
29 |
CO2-evolution [mg/l] |
0 |
8.9 |
13.8 |
16.3 |
18.6 |
24.9 |
28.6 |
29.5 |
Description of key information
The substance was tested in a valid CO2 evolution test according to OECD 301 B and under GLP. The substance is not readily biodegradable under the test condition.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.