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Diss Factsheets
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EC number: 219-986-0 | CAS number: 2591-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: not specified
- Type of information:
- other: publication
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available - Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Piperidine, 1-formyl-; N-Formylpiperidin; Formylpiperidine; N-Formylpiperidine; 1-Formylpiperidine; NFP; 1-Piperidinecarboxaldehyde; Piperidinoformamide
- Author:
- Canadian Centre for Occupational Health and Safety
- Year:
- 2 010
- Bibliographic source:
- Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010
Materials and methods
- Principles of method if other than guideline:
- database data, no information is given on test method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Piperidine-N-carbaldehyde
- EC Number:
- 219-986-0
- EC Name:
- Piperidine-N-carbaldehyde
- Cas Number:
- 2591-86-8
- Molecular formula:
- C6H11NO
- IUPAC Name:
- piperidine-1-carbaldehyde
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report) : Piperidine, 1-formyl-
- RTECS Number : TN0380000
- Synonyms/Trade Names : N-Formylpiperidin , Formylpiperidine , N-Formylpiperidine , 1-Formylpiperidine , NFP , 1-Piperidinecarboxaldehyde , Piperidinoformamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No details available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- No details available
- Details on mating procedure:
- No details available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No details available
- Duration of treatment / exposure:
- 6 - 20 days after conception
- Frequency of treatment:
- no data
- Details on study schedule:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
6600 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- No details available
- Positive control:
- No details available
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- other: TDLo
- Effect level:
- 6 600 other: mg/kg
- Based on:
- not specified
- Sex:
- female
- Basis for effect level:
- other: Reference : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume (issue)/page/year: 18,96,1992
- Remarks on result:
- other: Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Toxic Effects :
Reproductive - Fertility - postimplantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Applicant's summary and conclusion
- Executive summary:
Piperidine, 1-formyl- was studied for its reproductive toxicity potential in rats. For Piperidine, 1-formyl- at a dose level of 6600 mg/kg bw the following toxic effects were reported :
Reproductive - Fertility - postimplantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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