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EC number: 278-154-5 | CAS number: 75268-65-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 16 October 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: Internal method " Method A-11, Acute Fish Toxicity"
- Version / remarks:
- Equivalent to OECD Guideline 203
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- no
- Details on sampling:
- None
- Vehicle:
- not specified
- Details on test solutions:
- None
- Test organisms (species):
- other: Rainbow trout also known as Oncorhynchus mykiss (previous name: Salmo gairdneri); Zebra fish also known as Danio rario
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- None
- Test temperature:
- Rainbow trout: 16 °C
Zebra fish: 25 °C - pH:
- Rainbow trout: 7.8 - 8.1
Zebra fish: 8 - 8.1 - Dissolved oxygen:
- Rainbow trout: 8.3 - 8.8 mg/L
Zebra fish: 6.5 mg/L (only one reading taken. this reading was for the concentration 300 mg/L) - Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- Rainbow trout: 100, 300 and 1000 mg/L
Zebra fish: 100, 300 and 1000 mg/L - Details on test conditions:
- - No of fish tested for each concentration: 8 each for rainbow trout and 10 each for zebra fish
Refer " Any other information on material and methods incl. tables" for details - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 260 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: For test with rainbow trout
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 334 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: For test with Zebra fish
- Details on results:
- Test with rainbow trout: No mortality was observed at the concentration of 100 mg/L. Three out of 8 fish were found dead at the concentration of 300 mg/L, while 100 % mortality was observed with 1000 mg/L concentration. The 48 h and 96 h LD0 and LD100 of FAT 40138/A was 100 and 1000 mg/L, respectively.
Test with zebra fish: No mortality was observed at the concentration of 100 mg/L. One out of 10 fish were found dead at the concentration of 300 mg/L, while 100 % mortality was observed with 1000 mg/L concentration. The 48h and 96 h LD0 and LD 100 of FAT 40138/A was 100 and 1000 mg/L, respectively. - Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 for rainbow trout and zebra fish was determined to be 260 and 334 mg/L, respectively.
- Executive summary:
The acute fish toxicity of FAT 65042/C was assessed in a study conducted acccording to the internal Ciba method " Method A-11, Acute Fish toxicity", which is equivalent to OECD Guideline 203. In the test with rainbow trout, three groups of 8 fish each were exposed to 100, 300 and 1000 mg/l respectively for 96 hours. In the test with Zebra fish, three groups of 10 zebra fish each, were exposed to test concentrations of 100, 300 and 1000 mg/L for 96 hours. In the test with rainbow trout, no mortality was observed at the concentration of 100 mg/L, three out of 8 fish were found dead at the concentration of 300 mg/L, while 100 % mortality was observed with 1000 mg/L concentration. Similarly, in the test with zebra fish, no mortality was observed at the concentration of 100 mg/L, one out of 10 fish were found dead at the concentration of 300 mg/L, while 100 % mortality was observed with 1000 mg/L concentration. Hence, the LC50 for rainbow trout and zebra fish was determined to be 260 and 334 mg/L, respectively.
Reference
Description of key information
The 96 h LC50 of test substance in rainbow trout fish was determined to be 1000 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Toxicity potential of FAT 40138 based on short-term exposure was assessed with the help of two studies. In a key study, acute fish toxicity of FAT 40138/A was assessed according to the internal Ciba method " Method A-11, Acute Fish toxicity", which is equivalent to OECD Guideline 203. In the test with rainbow trout, three groups of 8 fish each were exposed to 100, 300 and 1000 mg/L for 96 h, respectively. In the test with zebra fish, two groups of 8 zebra fishes each, were exposed to test concentrations of 300 and 1000 mg/L for 96 h. No mortality was observed throughout the observation period with rainbow trout as well as zebra fish. Hence, the LC50 for test substance was determined to be >1000 mg/L. In a supporting study, the 96 h LC50 of FAT 40138/C for rainbow trout and zebra fish was determined to be 260 and 334 mg/L, respectively.
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