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Diss Factsheets
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EC number: 943-552-6 | CAS number: 91844-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was conducted according to methods similar to OECD guideline 402 (limit test) and was performed pre-GLP. A concise description of the protocol is available and results are reported clearly.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 7 day observation period
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Lemongrass oil
- IUPAC Name:
- Lemongrass oil
- Details on test material:
- - Name of test material (as cited in study report): Lemongrass E.I.
- Physical state: Liquid
- Lot/batch No.: Confidential
- Other: Test material received from RIFM on January 21, 1972
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.9 - 2.3 kg
ENVIRONMENTAL CONDITIONS
No information available
IN-LIFE DATES: No information available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: abdominal area (skin was abraded)
- Type of wrap if used: binders of rubber dam, gauze and adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw
VEHICLE
No information available - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 rabbits
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, and skin irritation - Statistics:
- not relevant
Results and discussion
- Preliminary study:
- not relevant
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mortality was observed in 1 animal
- Mortality:
- 1/10
- Clinical signs:
- other: No effects observed
- Gross pathology:
- No abnormalities were noted at necropsy
- Other findings:
- Skin irritation: Moderate erythema was noted in 7/10 animals, moderate signs of edema in 9/10 and moderate atonia in 2/10 animals
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal application of Lemongrass oil in 10 New Zealand White rabbits at a dose of 2000 mg/kg body weight resulted in 1 death animal. Therefore, the LD50 was established exceeding 2000 mg/kg and Lemongrass oil does not need to be classified for acute dermal toxicity according to the criteria outlined in Annex I of 1272/2008/EC (CLP), under the conditions of this study.
- Executive summary:
A single dose of 2000 mg/kg Lemongrass oil was applied dermally to the abraded abdominal skin of 10 New Zealand White rabbits. The treated skin site was covered with binders of rubber dam, gauze and adhesive tape for 24 hours. After 24 hours, the wrapping was removed and the rabbits were observed for mortality and toxicity for a period of 7 days.
Under the conditions of this study, dermal application of Lemongrass oil caused a mortality of 1/10 in New Zealand White rabbits at a dose of 2000 mg/kg body weight. Signs of skin irritation were observed as moderate erythema in 7/10 animals, moderate signs of edema in 9/10 and moderate atonia in 2/10 animals. In conclusion, the LD50 was established to be exceeding 2000 mg/kg and Lemongrass oil does not need to be classified for acute dermal toxicity according to the criteria outlined in Annex I of 1272/2008/EC (CLP), under the conditions of this study.
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