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EC number: 209-170-2 | CAS number: 557-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientifically defensible approach was used to conduct the study performed similar to OECD 423 guideline. No data on GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- Remarks:
- (No data on control animals)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 5970-45-6
- Cas Number:
- 5970-45-6
- IUPAC Name:
- 5970-45-6
- Reference substance name:
- Acetic acid, zinc salt, hydrate (2:1:2)
- IUPAC Name:
- Acetic acid, zinc salt, hydrate (2:1:2)
- Details on test material:
- - Name of test material (as cited in study report): Zinc acetate dihydrate
- Molecular formula (if other than submission substance): C4-H6-O4.Zn.2H2-O
- Molecular weight (if other than submission substance): 219.48
- Substance type: discrete
- Physical state: solid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: The animals were supplied by Panlab (Barcelona, Spain).
- Weight at study initiation: 230-280 g
- Diet (e.g. ad libitum): The animals had free access to a standard pellet diet (Panlab, Barcelona, Spain).
- Water (e.g. ad libitum): Ad libitum.
- Acclimation period: Rats were allowed to acclimatize for a period of 7 days after shipping before experimental use.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- Solutions of zinc were prepared and administered in 0 .9% saline.
Solution concentrations were adjusted so that a 300-g rat received 1 mL.
All solutions were given at pH between 6.0 and 7.0. Sodium bicarbonate was used to adjust the pH when necessary. - Doses:
- No data.
- No. of animals per sex per dose:
- Ten male animals in each group were used.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The LD50 values were then calculated according to the Litchfield and Wilcoxon method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 663.83 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 488.26 - 902.94
- Remarks on result:
- other: (Estimated results for Zinc Acetate anhydrous)
- Mortality:
- The majority of deaths were observed within the first 24 hr. No deaths occurred after 3 days.
- Clinical signs:
- other: The physical and clinical signs appeared within the first 48 hr. These signs included miosis, conjunctivitis, decreased food and water consumption and hemorrhages and hematomas in the tall. These changes decreased with time which would suggest a quick eli
Any other information on results incl. tables
The LD50 of zinc acetate anhydrous was 663.83 (488.26-902.94) mg/kg bw in male rats.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of zinc acetate anhydrous was 663.83 (488.26-902.94) mg/kg bw in male rats.
- Executive summary:
Zinc acetate dihydrate was administered po by gavage to male rats. Ten animals in each group were used. The LD50 values were then calculated according to the Litchfield and Wilcoxon method. Animals were observed for 14 days.
The LD50 of zinc acetate anhydrous was 663.83 (488.26-902.94) mg/kg bw in male rats.
The majority of deaths occurred during the first 48 hr. The clinical and physical signs appearing after intoxication included miosis, conjunctivitis, decreased food and water consumption and hemorrhages and hematomas in the tall. These changes decreased with time which would suggest a quick elimination of zinc.
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