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reaction mass of Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[[4-[bis(2- hydroxyethyl)amino]-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium salt and Benzenesulfonic acid, 5-[[4-[bis(2-hydroxyethyl)amino]-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-2-[2-[4-[[4-[(2-hydroxyethyl)amino]-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl]-, disodium salt
EC number: 942-661-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
APPEARANCE AND STATE
Leucophor 1501X is a yellow powder at 20 °C and 1013 hPa; it is primarily marketed/used in a non solid or granular form, therefore the particle size is not relevant for Chemical Safety Assessment.
During the DSC analysis neither melting point, nor boiling point was recorded up to 480 °C; at 95.0 ± 0.8 °C evaporation of crystal water was observed. The signal recorded at about 480 °C has been attributed to decomposition.
The density of Leucophor 1501 X is approximately 1 g/cm3 at room temperature.
Based on the physicochemical properties of the substance, the experimental measurements of properties like vapour pressure (estimated 0.000000001 Pa, at 25 °C),surface tension, flash point can be avoided, while viscosity determination is technically not feasible.
SOLUBILITY and PARTITION COEFFICIENT
The solubility of Leucophor 151X in water was determined by measurement of the test item concentration in the filtrated test solutions using photometry. The main test was performed two times. All filtrated test solutions showed no Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid). At the plateau, the concentration of substance in water had reached 67.28 ± 4.24 g/l at 20.0 ± 0.5 °C and pH ca 9 (Affolter, 2016).
Leucophor 1501X is a Stilbene Fluorescent Whitening Agents salt, which is a class of compounds known to be water-soluble, based on the characteristically chemical structure and the functional groups. The sulphonate and the hydroxyl substituent groups contribute to the hydrophilicity of the substance.
The test item is also expected to possess a greater affinity with the water phase than the octanol one, leading to a negative partition coefficient log Kow. As many salts and as many Stilbene Fluorescent Whitening Agents, a negative partition coefficient can be considered as representative for the substance under investigation.
This conclusion can be supported by the outcomes of the partition coefficient investigation performed on the similar substance 01. The test item is very water soluble (i.e. > 608 g/l), as Leucophor 1501X.
During the preliminary test, a very good solubility in water and a poor solubility in n-octanol were found indicating a partition coefficient below -2. Hence, a main test according to testing Guidelines (either HPLC or flask shaking method) could not be applied. Therefore the partition coefficient of the test item was estimated using the solubility data in n-octanol (as obtained in the preliminary test) and in water (Weissenfeld, 2005).
Under environmental conditions, Leucophor 1501X dissociates completely in water.
PHYSICAL HAZARDS
Leucophor 1501X does not ignite and propagate combustion; the screening evaluation failed to evidence reasons of concern, on the basis of the chemical structure analysis and the thermal behaviour investigation.
It does not meet the criteria to be considered as flammable/explosive/oxidising.
READ ACROSS APPROACHES
All the substances used in a read across approach are Stilbene derivatives Fluorescent Whitening Agents salts. They display similar structural and physicochemical properties: all of them exhibit a comparable thermal behaviour; furthermore they present high degree of dissociation in water and very low octanol/water partition coefficients because to a higher affinity with water phase than the octanol one. They are all very soluble in water, due to the presence of sulphonated groups in the molecules.
The common starting compound and the similar treatment let to expect that all the analogues would be characterized by a comparable impurity profile. Residues of salification, water and by-product(s) from manufacturing process can be present in variable percentage ranges. The impurity profile is not expected to significantly impact the physicochemical properties.
The read across approach can be considered as reliable and representative; the differences occurring in the structure formulas (i.e. substituents) are expected to not significantly impact the physical and chemical characterisation.
Further details about the justification for read across approach are given in the report attached to the Section 13 of this dossier.
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