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Diss Factsheets
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EC number: - | CAS number: 1309389-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin corrosion: not corrosive (OECD 431, GLP)
Skin irritation: not irritating (draft OECD 439, GLP)
Eye irritation: not irritating (OECD 437 (2013); GLP)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
WoE, Skin irritation in vitro, RL2
In an in vitro skin irritation study, the substance was tested for its skin irritation potential according to OECD guideline 439 (draft 2008) by the means of the human skin model test using EpiDerm™. Triplicates of EpiDerm™ tissues were exposed to either the substance (25 µL) with the vehicle (25 µL), the positive control (5 % sodium lauryl sulphate; 30 µL), or the negative control (sterile PBS; 30 µL) for 1 hour. The substance and the positive and negative controls were washed off the skin tissues after treatment. After further incubation for about 42 hours the tissues were treated with the MTT solution for 3 hours. The formazan that was metabolically produced by the tissues was extracted by incubation of the tissues in isopropanol for at least 2 hours followed by the measurement of the optical density (OD570).
After an 1 hour exposure period with the test item the relative tissue viability increased (105 %) (threshold for irritation: 50 %). Therefore, the substance is not considered to possess an irritant potential.The controls confirmed the validity of the study.
According to the Regulation (EC) No 1272/2008 and subsequent adaptations, the substance does not require classifiication as skin irritant.
WoE, Skin corrosion in vitro, RL1
In an in vitro skin corrosion study, the substance was tested for its skin corrosive potential according to the OECD guideline 431 (2004) by the means of the human skin model test using EpiDerm™. Duplicates of EpiDerm™ tissues were exposed to either the substance (25 µL) with the vehicle (25 µL), the positive control (8 n potassium hydroxide; 50 µL) or the negative control (highly de-ionised water; 50 µL) for each of two different exposure periods: 3 minutes and 1 hour. Afterwards the test and the control items were rinsed off the tissues, and a 3 hour incubation period with MTT solution followed.
After incubation, tissues were washed and the formazan produced by the tissues was extracted with isopropanol overnight. This was followed by the measurement of the optical density (OD570).
After an exposure period of 3 minutes the relative tissue viability increased to 123 % (threshold for corrosivity: 50 %). After an exposure period of 1 hour the relative tissue viability increased to 104 % (threshold for corrosivity: 15 %). Therefore, the substance was not considered to be corrosive. The controls confirmed the validity of the study.
According to the Regulation (EC) No 1272/2008 and subsequent adaptations, the substance is not corrosive to the skin.
Key, In Vitro Eye irritation, RL1
In an in vitro eye irritation study, the substance was tested for its eye irritation potential according to the OECD guideline 437 (2013) using fresh bovine corneae. Three corneae were exposed to either the test item as 20 % suspension (w/v) (0.75 mL), the positive control ( 10% (w/v) Benzalkonium chloride in 0.9% (w/v) NaCl (saline)); 0.75 mL), or the negative control (saline; 0.75 mL) for 240 minutes (incubation temperature: 32 ± 1 °C). After the incubation phase the substance, the positive control, and the negative control were each rinsed from the corneae. Next, the corneal opacity and permeability were measured and the In vitro Irritancy Score (IVIS) was calculated for the test item and the controls.
Relative to the negative control, the substance did not cause an increase of the corneal opacity or permeability.
The calculated mean IVIS was 2.62 (threshold for serious eye damage: IVIS≥ 55). According to OECD 437 (2013) a chemical that induces an IVIS ≤ 3 is considered as not requiring classification for eye irritation or serious eye damage. According to the Regulation (EC) No 1272/2008 and subsequent adaptations, the substance is not irritating to the eye.
Justification for classification or non-classification
Skin irritation
The substance does not possess a skin irritating or corrosive potential based on in vitro OECD 431 and OECD 439 tests and does not require classification as skin corrosive according to Regulation (EC) No 1272/2008, as amended for the eighteenth time in Regulation (EU) 2022/692.
Eye irritation
The substance does not possess an eye irritation potential according to an in vitro OECD 437 test and does not require classification as eye irritant according to Regulation (EC) No 1272/2008, as amended for the eighteenth time in Regulation (EU) 2022/692.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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