Registration Dossier
Registration Dossier
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EC number: 200-625-0 | CAS number: 66-27-3
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Methyl methanesulfonate (CAS no. 66-27-3). The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of -0.71 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of Methyl methanesulfonate was determined to be 3 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Methyl methanesulfonate is considered to be non-accumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic / sediment
Experimental study and various predicted data for the target compound Methyl methanesulfonate (CAS No. 66-27-3) and various supporting studies for its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative database (HSDB and PubChem, 2017), bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Methyl methanesulfonate (CAS no. 66-27-3). The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of -0.71 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of Methyl methanesulfonate was determined to be 3 dimensionless.
In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical Methyl methanesulfonate (CAS No. 66 -27 -3). The bioconcentration factor (BCF) of Methyl methanesulfonate was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).
In a supporting study from authoritative database (HSDB, 2017) for the read across chemical Isopropyl methanesulphonate (CAS no. 926-06-7), the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of read across chemical isopropyl methanesulphonate. The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of 0.25 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of isopropyl methanesulphonate was determined to be 3 dimensionless.
For the read across chemical Methanesulphonyl chloride (CAS no. 124-63-0), bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of read across chemical methanesulphonyl chloride (HSDB, 2017). The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of 1.3 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of methanesulphonyl chloride was determined to be 1.9 dimensionless.
On the basis of above results for target chemical Methyl methanesulfonate (from authoritative database HSDB,PubChemand EPI suite,2017) and for its read across substance (from authoritative database HSDB, 2017), it can be concluded that the BCF value of test substance Methyl methanesulfonate ranges from 3.0 – 3.162 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Methyl methanesulfonate is not expected to bioaccumulate in the food chain.
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