Registration Dossier
Registration Dossier
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EC number: 207-074-5 | CAS number: 431-47-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Annex VIII of the REACH regulation mentions that the assessment of the toxicokinetic behaviour of the substance should be reported to the extent that can be derived from the relevant available information. From the search done for available data, it is reported that no known toxicity data is available for methyl trifluoroacetate.
The methanol hydrolytic half-life of methyl trifluoroacetate is less than 1 minute. Methanol and trifluoroacetic acid result from the reaction with water in the mucous membranes, upper respiratory tract, eyes and skin. Methanol is harmful and exposure to liquid or vapors may cause blindness or death. While the toxicity of trifluoroacetic acid is low, contact with the skin may cause burns. The acid diffuses into the affected tissue and destroys as it penetrates. Fumes may also be irritating. Wash any affected area for at least 15 minutes and treat as third degree burn even though appearance may not indicate severity of skin damage.
Thus, in the light of the above information, conducting a toxico-kinetic study for methyl trifluoroacetate seems scientifically unjustified.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Annex VIII of the REACH regulation mentions that the assessment of the toxicokinetic behaviour of the substance should be reported to the extent that can be derived from the relevant available information. From the search done for available data, it is reported thatno known toxicity data is available for methyl trifluoroacetate.
The methanol hydrolytic half-life of methyl trifluoroacetate is less than 1 minute. Methanol and trifluoroacetic acid result from the reaction with water in the mucous membranes, upper respiratory tract, eyes and skin. Methanol is harmful and exposure to liquid or vapors may cause blindness or death. While the toxicity oftrifluoroacetic acid is low, contact with the skin may cause burns. The acid diffuses into the affected tissue and destroys as it penetrates. Fumes may also be irritating. Wash any affected area for at least 15 minutes and treat as third degree burn even though appearance may not indicate severity of skin damage.
Thus, in the light of the above information, conducting a toxico-kinetic study for methyl trifluoroacetate seems scientifically unjustified. In addition, there is very low possibility of the chemical being ingested within the living system, except accidentally. If this occurs, there shall be no bioaccumulation due to injury to the internal organs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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