Registration Dossier
Registration Dossier
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EC number: 233-546-5 | CAS number: 10226-30-9
Endpoint summary
Administrative data
Description of key information
Additional information
Adsorption / desorption:
The predicted data for the test compound 6-Chlorohexan-2-one (CAS No. 10226-30-9) and the study for its read across substance was reviewed for the adsorption end points which are summarized as below:
From EPI suite (KOCWIN Program (v2.00));2016 predicted model for test substance 6-Chlorohexan-2-one indicate that the soil Adsorption Coefficient i.e Koc value was estimated as Koc 27.3 L/kg(log Koc=1.436) by means of MCI method at 25 deg.C. This indicates that the substance 6-chlorohexan-2-one has negligible sorption to soil and sediment with rapid migration potential to groundwater.
Other predicted database for target chemical indicate that Koc value at pH 1-10 was found to be 152(Log koc= 2.1818) at 25 deg.C this Koc Value concluded that the test substance 6-chlorohexan-2-one have the tendency to Low sorption to soil and sediment and therefore moderate migration potential to groundwater.( SciFinder,Advanced Chemistry Development (ACD/Labs) Software V11.02;2016)
Experimental study for read across substance Octan-2-one (111-13-7) from HSDB database indicate that the adsorption coefficient (Koc) was found to be 460 using a measured log Kow of 2.37 and a regression derived equation. This Koc value suggests that 2-octanone is expected to have moderate mobility in soil.
From Scifinder database the prediction done for following three read across substance as:
*Methyl 4-chlorobutyrate (Cas no. 3153-37-5) - 121(Log koc= 2.082) at pH 1-10
*1-Propanol, 3-chloro-, acetate (Cas no. 628-09-1) - 125(Log koc= 2.0969) at pH 1-10
*6-bromohexan-2-one (Cas no. 10226-29-6) - 195(Log koc= 2.290)
Above all predicted Koc Values concluded that the all three substances have the tendency to Low sorption to soil and sediment and therefore moderate migration potential to groundwater.
Thus based on the overall available information it is concluded that the test substance 6-Chlorohexan-2-one (CAS No. 10226-30-9) have tendency negligible to low sorption to soil and sediment.
Henry's Law constant:
Henry's Law constant of test substance 6-chlorohexan-2-one was estimated to be 4.14 Pa m³/mol at 25 deg.C
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