Tantalum pentachloride

Endpoint summary

Description of key information

For tantalum pentachloride acute toxicity data is available for the oral route. Cochran et al. (1950) published a LD50 of 1900 mg/kg bw in rat for both sexes.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Publication, which meets generally accepted scientific standards.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Study is an acute oral toxicity, but as the study is from 1950 no OECD guideline for acute oral toxicity was available at that time

GLP compliance:

no

Test type:

other: acute oral toxicity

Limit test:

no

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): purina chow, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
The animals were maintained in air-conditioned rooms

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

A 50% aqueous solution of the salt was injected as the solubility permitted.

Doses:

No information was provided

No. of animals per sex per dose:

In total 22 rats were treated

Control animals:

not specified

Details on study design:

The solution was given in single doses orally by stomach tube. All animals were observed for ten days. It was found that a ten day observation period was sufficient, since animals either succumbed or recovered during this period.

Statistics:

The LD50 values were obtained from ten day mortality data by using the log-probability method.

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 900 mg/kg bw

Based on:

test mat.

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The oral LD50 value in rats after treatment with tantalum pentachloride was determined in a pre-OECD study to be 1900 mg/kg body weight.

Executive summary:

In an acute oral toxicity study male and female Sprague-Dawley rats (in total 22 rats) were orally treated with tantalum pentachloride in water. Animals were observed for 10 days. Based on the mortality, an oral LD50 of 1900 mg/kg bw was determined for both sexes.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

1 900 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

As published by Cochran eta l. (1950), male and female rats were administered orally with the target substance tantalum pentachloride in an acute oral toxicity study. The animals were observed for a total of 10 days. Based on mortality, the LD50 was determined to be 1900 mg/kg bw for both sexes. Date for another routes of exposure are not provided as a classification for Skin Corr. 1B already triggers appropriate risk management measures. 

Justification for selection of acute toxicity – oral endpoint
Publication, which meets generally accepted scientific standards

Justification for classification or non-classification

Based on the available data, tantalum pentachloride warrant classification for acute oral toxicity Category 4 (H302) in accordance to regulation (EC) No 1272/2008.