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EC number: 204-133-7 | CAS number: 116-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 26, 2020 to November 18, 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The water solubility of Safranal at 20°C is 514.9 mg/I. According to the guidelines, the initial concentration to be used for the hydrolysis reaction should not exceed the half of the saturation concentration, or a concentration of 0.01 mol/1.
A nominal concentration of 200 mg/I was used in the preliminary test. Therefore, 200 mg of test substance were added in a 1000 ml volumetric flask and completed with buffer solution. The HPLC method is capable of quantifying concentrations of this magnitude.
Preliminary test at 50°C (Tier 1) : Solutions of Safranal P in the different buffer solutions were prepared as described above. For each pH, a minimum of 24 amber glass crimp cap vials (20 ml) were filled with 20 ml of the respective solution, sealed with Teflon coated rubber septa crimp cap, and placed in the water bath at 50°C. After temperature equilibration, a first pair of vials was extracted for each pH. This is time zero of the experiment. At given times, namely after 120 h, other two vials per buffer solution were sacrificed for analysis. - Buffers:
- pH 4: Ready-made concentrate (Titrisol®, MERCK, Darmstadt, Germany, art. No. 9884, citrate I hydrochloric acid buffer) pH 4.00 ± 0.02 at 20°C
pH 7: Ready-made concentrate (Titrisol®, MERCK, Darmstadt, Germany, art. No. 9887, phosphate buffer) pH 7.00 ± 0.02 at 20°C
pH 9: Ready-made concentrate (Titrisol®, MERCK, Darmstadt, Germany, art. No. 9889, boric acid / potassium chloride / sodium hydroxide buffer) pH 9.00 ± 0.02 at 20°C
In order to avoid any unnecessary excess of inorganic salts that could reduce the solubility of the test substance, these buffer solutions were diluted to 10% with ultrapure water before being used as test media. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 165.04 mg/L
- Remarks:
- Average concentration of 2 measured values
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 160.62 mg/L
- Remarks:
- Average concentration of 2 measured values
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 156.39 mg/L
- Remarks:
- Average concentration of 2 measured values
- Number of replicates:
- 2
- Transformation products:
- not measured
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Details on results:
- Only a preliminary test was performed. This is aligned with the criterion given in the guidelines:
If less that 10% degradation after 120hours (equivalent to a half-life time higher that 1 year at 25 degrees Celsius) is observed, no further testing is necessary.
This criterion is fulfilled for pH 4, pH 7 and pH 9. For all three pH <10% degradation was observed at 50 degrees Celsius over a 120 hours period (0h to 120h).
Analytical results are given in Table 1 of the study report. - Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life time of Safranal P at 25°C is higher than one year at pH 4, pH 7 and pH 9.
- Executive summary:
An abiotic degradation study (hydrolysis as a function of pH) was carried out with Safranal P according to OECD guideline n° 111.
Only the preliminary test needed to be performed at pH 4, pH 7 and pH 9 since, at 50°C, less than 10% hydrolysis occurred after 120 h.
A hydrolysis of less than 10% after 120 h, or more, at 50°C corresponds to a half-life time of more than one year at 25°C.
Therefore: The half-life time of Safranal P at 25°C is higher than one year at pH 4, pH 7 and pH 9.
Reference
Description of key information
An abiotic degradation study (hydrolysis as a function of pH) was carried out with Safranal P according to OECD guideline n° 111.
Only the preliminary test needed to be performed at pH 4, pH 7 and pH 9 since, at 50°C, less than 10% hydrolysis occurred after 120 h.
A hydrolysis of less than 10% after 120 h, or more, at 50°C corresponds to a half-life time of more than one year at 25°C.
Therefore: The half-life time of Safranal P at 25°C is higher than one year at pH 4, pH 7 and pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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