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Diss Factsheets
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EC number: 203-564-8 | CAS number: 108-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- BASF Test:
Young adult laboratory mice were used. The concentrations of the test substance were applied as a single interperitoneal dose. The post-exposure period was 14 days, after which the animals were sacrificed and subjected to gross-pathological examination. Groups of 5 male and 5 female mice were exposed to concentrations of the test substance as specified. Clinical symptoms were recorded immediately following injection, and 15 min, 30 min, 1 h, 2 h, 4 h, 5 h, 7 d and 14 d thereafter. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Acetic anhydride
- Analytical purity: approx. 98%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Wiga, Sulzfeld
- Age at study initiation: not recorded
- Weight at study initiation: males 28 g, females 27 g (mean)
- Fasting period before study: approx. 16 hours
- Diet (ad libitum): Herilan MHR-Kraftfutter
- Water (ad libitum): yes
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Doses:
- 46.4, 68.1, 100, 147 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 50 mg/kg bw
- Mortality:
- No animals died in any dose group 1 hour after substance application. In the lowest dose group, 1/5 male animals were found dead after 24 h and 2/5 males and 1/5 females, 3/5 males and 1/5 females, 3/5 males and 1/5 females, respectively, after 48 h, 7 days and 14 days. In the 68.1 mg/kg bw dose group, 1/5 males was found dead after 48 h, whereas 4/5 males and 4/5 females died after 7 days; after 14 days all animals had died. In case of the 100 mg/kg bw group, 2/5 males died after 24 h, 4/5 males and 2/5 females after 48 h and 5/5 males and 5/5 females after 7 days. 5/5 males and 3/5 females were found dead after 24 hours and all animals of that dose group had died after 48 h.
- Clinical signs:
- The animals of all dose groups showed dyspnea, apathy, staggering, paresis of the hind legs, twitching, tremor, spastic movements, convulsions in varying degrees and deteriorated general state.
- Body weight:
- not recorded
- Gross pathology:
- Gross pathological examination revealed an agglutinated liver in case of the two low dose groups and intraabdominal substance precipitation in case of one male of the 68.1 mg/kg bw dose group, but not in case of the two female animals of the same dose group; substance precipitation was also found in animals of the 100 mg/kg bw dose group. Both sexes showed comparable results.
Any other information on results incl. tables
Dose(mg/kg bw) |
Mortality Dead/treated |
|||||||||
1 hour |
24 hours |
48 hours |
7 days |
14 days |
||||||
male |
female |
male |
female |
male |
female |
male |
female |
male |
female |
|
46.4 |
0/5 |
0/5 |
1/5 |
0/5 |
2/5 |
1/5 |
3/5 |
1/5 |
3/5 |
1/5 |
68.1 |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
0/5 |
4/5 |
4/5 |
5/5 |
4/5 |
100 |
0/5 |
0/5 |
2/5 |
0/5 |
4/5 |
2/5 |
5/5 |
5/5 |
5/5 |
5/5 |
147 |
0/5 |
0/5 |
5/5 |
3/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.