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Diss Factsheets
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EC number: 201-730-4 | CAS number: 87-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In total, 50 rats (10 rats/dose) were treated by oral route with a single dose of the test item at dose 830 mg/kg, 1040 mg/kg, 1310 mg/kg, 2050 mg/kg and 5000 mg/kg.
Following dosing, the animals were observed during 14 days. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Isobutyl salicylate
- EC Number:
- 201-729-9
- EC Name:
- Isobutyl salicylate
- Cas Number:
- 87-19-4
- Molecular formula:
- C11H14O3
- IUPAC Name:
- Isobutyl salicylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 830 mg/ kg bw, 1040 mg/kg bw, 1310 mg/kg bw, 2050 mg/kg bw, 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 310 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3/10 at dose level 1040 mg/kg bw
5/10 at dose level 1310 mg/kg bw
8/10 at dose level 2050 mg/kg bw
9/10 at dose level 5000 mg/kg bw - Clinical signs:
- other: No clinical signs were observed
- Gross pathology:
- Skin irritation was observed: slight redness in 4/8 animals, moderate redness in 2/8 animals, and slight edema in 2/8 animals
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test item had an LD50 of 1310 mg/kg in the current study.
- Executive summary:
In the current study the acute oral toxicity of the test item was assessed. The methodology of the study was not described, therefore, it is assumed it was not according to OECD guideline. It was not indicated that the study was according to GLP.
In total 50 rats (10 rats/dose) were treated by oral route with a single dose of the test item at dose 830 mg/kg, 1040 mg/kg, 1310 mg/kg, 2050 mg/kg and 5000 mg/kg.
Following dosing, the animals were observed for 14 days.
At dose level 1040 mg/kg bw, 3/10 animals died on Day 2 after dosing. At dose level 1310 mg/kg, 5/10 animals died (3 on Day 1 after dosing and 2 on Day 2 after dosing). At dose level 2050 mg/kg, 8/10 animals died (1 on Day 1 after dosing and 7 on Day 2 after dosing). At dose level 5000 mg/kg, 9/10 animals died (3 on Day 1 after dosing, 5 on Day 2 after dosing and 1 on Day 3 after dosing).
No clinical signs were observed. Body weight was not specified in the study report. Skin irritation occurred: slight redness in 4/8 animals, moderate redness in 2/8 animals, and slight edema in 2/8 animals.
As the test item induced the death of the half of the animals at dose level 1310 mg/kg, the test item should be classified according to 1272/2008 CLP regulation as Acute Oral toxicity Category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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