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Diss Factsheets
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EC number: 943-210-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 17, 1978 to May 1, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- tetrasodium 15-[(Z)-2-{4-[(E)-2-{4-[(E)-2-{2,5-dimethyl-4-[(E)-2-(4-sulfophenyl)diazen-1-yl]phenyl}diazen-1-yl]-2-sulfophenyl}ethenyl]-3-sulfophenyl}diazen-1-yl]-10,12-dioxa-2,3-diaza-11-cupratricyclo[11.4.0.0^{4,9}]heptadeca-1(17),2,4,6,8,13,15-heptaene-6-sulfonate
- EC Number:
- 943-210-6
- Molecular formula:
- Not applicable. UVCB Substance
- IUPAC Name:
- tetrasodium 15-[(Z)-2-{4-[(E)-2-{4-[(E)-2-{2,5-dimethyl-4-[(E)-2-(4-sulfophenyl)diazen-1-yl]phenyl}diazen-1-yl]-2-sulfophenyl}ethenyl]-3-sulfophenyl}diazen-1-yl]-10,12-dioxa-2,3-diaza-11-cupratricyclo[11.4.0.0^{4,9}]heptadeca-1(17),2,4,6,8,13,15-heptaene-6-sulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Ace Animals, Boyertown, Pennsylvania- Weight at study initiation: 2.0 and 3.1 kgThe animals were fed, housed and maintained in accordance with standard laboratory procedures
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE- % coverage: 30 % of each animal's skin surfaceREMOVAL OF TEST SUBSTANCE- Washing (if done): yes , with warm water- Time after start of exposure: 24 hours after the star
- Duration of exposure:
- 24 hours
- Doses:
- 3000 mg/kg bw
- No. of animals per sex per dose:
- 3 per sex per dose
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: daily- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 3 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 2 700 mg/kg bw
- Based on:
- act. ingr.
- Clinical signs:
- There were no adverse clinical signs observed in any of the six animals throughout the study
- Body weight:
- Individual body weight fluctuations presented no consistent pattern of significance.
- Gross pathology:
- Necropsies revealed all organs to be within normal limits.
Any other information on results incl. tables
All animals exhibited erythema and edema on day one. On day 2, two animals showed oedema and two animals showed erythema. On the 3rd day of scoring, two animals displayed oedema and one animal displayed erythema. This lasted until day four. On day 5 and 6, one animal showed oedema and one animal showed erythema. By day 7, all animals were normal and remained so throughout the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- not classified according to CLP Regulation (EC n. 1272/2008)
- Conclusions:
- The test substance at a dose level of 3000 mg/kg bw, produced oedema and erythema up to day 6, but no mortality, therefore the LD0 = 3000 mg/kg bw (2700 mg/kg b.w based on active ingredient)
- Executive summary:
New Zealand albino rabbits, when exposed dermally to the test substance at a dose level of 3000 mg/kg bw, corresponding to 2700 mg/kg bw based on active ingredient, produced oedema and erythema up to day 6, but no mortality. All gross necropsies were within normal limits. Within 7 days of observation period all animals were normal and remained so throughout the study.
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