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EC number: 415-490-5 | CAS number: 141773-73-1 HELVETOLIDE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-01-07 to 2013-01-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. Validity criteria are fulfilled. Substance identification is specified with purity and isomers composition. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP compliance programme (inspected on 18-20 June 2012 / signed on 19 September 2012)
- Type of method:
- flask method
- Remarks:
- modified with slow-stirring
- Specific details on test material used for the study:
- Storage condition of test material: Room temperature.
- Key result
- Water solubility:
- 4.7 mg/L
- Incubation duration:
- 43 - 73 h
- Temp.:
- 20 °C
- pH:
- 6.4 - 6.5
- Remarks on result:
- other: in purified water
- Water solubility:
- 4.6 mg/L
- Temp.:
- 20 °C
- pH:
- 7.5 - 7.8
- Remarks on result:
- other: in daphnia reconstituted medium
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
- Executive summary:
The water solubility of the test substance was measured according to the OECD 105 guideline, flask method modified with slow stirring, in both pure water and daphnia medium.
Four samples were taken from 43 to 73 hours stirring at 20°C, and analysed by GC. Quantification was derived from bracketing standards, and linearity was checked. The average value of all samples was retained, as equilibrium was considered to be reached.
The solubility of the test substance is similar in both pure water and reconsituted natural (daphnia) medium, respectively 4.7 and 4.6 mg/L at 20°C, and neutral pH.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994-04-20 to 1994-06-02
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. Purity is specified, however batch number is not identified, so the isomers composition could not be retrieved from the notifier. Moreover, the study shows several weaknesses, and the test substance is likely to volatilize. Therefore validation cannot be granted.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- samples prepared at 20 times the saturation level instead of 5 times
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP compliance programme (inspected on 31 January 1994 / signed on 16 March 1994)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Storage condition of test material: metal canister at 4°C in the dark.
- Water solubility:
- >= 2.74 mg/L
- Temp.:
- 20 °C
- pH:
- 6.9 - 7.4
- Conclusions:
- slightly soluble (0.1-100 mg/L)
- Executive summary:
The water solubility of the test substance was measured under GLP, according to EU A6 guideline, flask method.
Measurements were performed by GC analysis. The mean of results at 48 and 72h was retained, and considered as a limit value, due to observed decrease in concentration; volatilisation is suspected.
The water solubility of the test substance is at least 2.74 mg/L at 20°C and pH 6.9 -7..4.
Referenceopen allclose all
Purified water
Time (hours) at 20°C | Concentration (mg/L) |
pH | ||
Vessel A | Vessel B | Vessel A | Vessel B | |
43.0 | 4.50 | 4.50 | 6.4 | 6.4 |
49.5 | 4.77 | 4.55 | 6.5 | 6.5 |
66.5 | 5.09 | 4.60 | 6.4 | 6.4 |
73.0 | 4.95 | 4.67 | 6.5 | 6.5 |
Mean solubility = 4.70 ± 0.22 mg/l (RSD = 4.6%)
Daphnia medium
Time (hours) at 20°C | Concentration (mg/L) |
pH | ||
Vessel A | Vessel B | Vessel A | Vessel B | |
43.0 | 4.50 | 4.22 | 7.7 | 7.8 |
49.5 | 4.50 | 3.89 | 7.8 | 7.8 |
66.5 | 5.20 | 4.98 | 7.5 | 7.6 |
73.0 | 4.41 | 4.79 | 7.6 | 7.6 |
Mean solubility = 4.56 ± 0.42 mg/l (RSD = 9.2%)
The detector calibration was found to be linear over the range 0 to 30 mg/l of standard solutions in hexane with a regression coefficient (r) of 1.0000.
Quantitative recoveries from fortified control samples in purified water and Daphnia medium were achieved (99 and 102% respectively), whilst no significant interfering peaks were evident in blank control solutions.
The preliminary tetst determined the water solubility to be less than 40 mg/L.
The peak heights relating to the standard and sample solutions are detailed below:
Solution | Mean total peak height |
Standard 102 mg/L | 1.284 x 105 |
Standard 109 mg/L | 1.307 x 105 |
Sample 1 | 1.032 x 105 |
Sample 2 | 8.590 x 104 |
Sample 3 | 8.223 x 104 |
The concentration of test material in the sample solutions is shown in the table below:
Sample number | Time shaken at ca 30°C (hours) | Time equilibrated at 20°C (hours) | Concentration (mg/L) | Solution pH |
1 | 25 1/2 | 25 1/4 | 3.36 | 7.2 |
2 | 49 | 24 1/2 | 2.80 | 6.9 |
3 | 72 1/4 | 24 | 2.68 | 7.4 |
As the reproducibility is more than 15% between samples 1 and 2, the retained value will be the mean of samples 2 and 3.
Description of key information
Slighlty soluble in pure water: 4.7 mg/L at 20°C (pH of saturated solution 6.5);
and in natural medium: 4.6 mg/L at 20°C.
Calculated as sum of isomers.
Key value for chemical safety assessment
- Water solubility:
- 4.7 mg/L
- at the temperature of:
- 20 °C
Additional information
An old study (SPL 1994), despite conducted according to EC guideline and GLP, could not be assigned as reliable, mainly because of decrease in concentration observed during the experiment. It was not disregarded because testing fulfilled method requirements, but the result can only be considered as a lower limit value, therefore unsufficient for purpose. As no degradation was anticipated in the conditions considered, volatilisation was suspected.
A new, fully reliable experimental study (HLS 2013), was conducted according to a recognized ISO/EC method and under GLP, in closed conditions. It is considered as the key study, and the result is retained as key data for purpose of CSA.
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