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EC number: 284-635-0 | CAS number: 84961-46-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum cassia, Lauraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- ECHA Guidance Chapter R.7a (2017) describes that substances with a positive result in an open epicutaneous test may be considered as a potential skin sensitiser.
Data source
Reference
- Reference Type:
- publication (copyright not owned for reproduction)
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: allergenicity assessment
- Short description of test conditions: Three consecutive phases. 1) Pretesting phase: establisching the primary irritating threshold concentration of test substances. Provides the baseline data for each material to be tested on guinea pigs. 2) Induction phase: 3-week period of daily open applications of the test material, usually to the same skin site. 3) Challange phase: determination whether sensitization has occurred or not.
- Parameters analysed / observed: minimal irritating and maximal nonirritating concentration both determined by all-or-none criteria - GLP compliance:
- not specified
- Type of study:
- open epicutaneous test
- Justification for non-LLNA method:
- The LLNA method (developed in 1989) was not available yet by the time the study was conducted (1985).
Test material
- Reference substance name:
- Cinnamomum cassia, ext.
- EC Number:
- 284-635-0
- EC Name:
- Cinnamomum cassia, ext.
- Cas Number:
- 84961-46-6
- IUPAC Name:
- (2E)-3-(2-methoxyphenyl)prop-2-enal; (2E)-3-phenylprop-2-en-1-yl acetate; (2E)-3-phenylprop-2-enal
- Test material form:
- liquid
- Remarks:
- Yellow colour
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- 100%, 30%, 10%, 3%,1% and 0,3%
- Day(s)/duration:
- Day 0-20
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- A: minimal irritating concentration
B: A/3 maximal nonirritating concentration
C: B/3
D: C/3 - Day(s)/duration:
- 21-35
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 10 (controls), min 6 (in test groups)
- Details on study design:
- RANGE FINDING TESTS:
- Timepoint: 1 day before starting the induction procedure
- No. of exposures: 1
- Amount: 0.025 ml
- Concentrations: 100, 30, 10, 3 and 1% simultaneously
- Site: 2 cm2 of the flank skin (clipped and marked with a circular stamp)
- Evaluation: 24h after application of the test material
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 20/21 (daily for 3 weeks or 5 times weekly during 4 weeks)
- Exposure period: -
- Test groups: TS in vehicle
- Control group: No pretreatment or Vehicle
- Site: 8cm2 on the flank skin (uncovered)
- Frequency of applications: daily for 3 weeks or 5 times weekly for 4 weeks
- Duration: 0-20 d
- Concentrations: 100%, 30%, 10%, 3%, 1% and 0,3%
B. CHALLENGE EXPOSURE
- No. of exposures: 2
- Day(s) of challenge: 21 and 35
- Exposure period: -
- Test groups: TS in vehicle
- Control group: TS in vehicle
- Site: contralateral flank
- Concentrations: 4 different; named A, B, C, D
- Evaluation (hr after challenge): 24, 48, 27
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Key result
- Reading:
- other: not specified
- Group:
- test chemical
- Dose level:
- results very concise and only qualitative
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- OET
- Key result
- Reading:
- other: not specified
- Group:
- test chemical
- Dose level:
- 4%
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- in HMT/RIPT is mentioned in this publication but is not described in detail
Applicant's summary and conclusion
- Interpretation of results:
- other: Substance is a potential skin sensitiser
- Conclusions:
- Cassia oil tested positive in human (4% in HMT/RIPT) and guinea pigs (OET) sensitisation tests.
- Executive summary:
Cassia oil was found to be sensitising in human (4% in HMT/RIPT) and guinea pigs (OET) and is therefore considered to be a potential skin sensitiser.
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