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Diss Factsheets
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EC number: 223-095-2 | CAS number: 3734-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Denatonium benzoate is an animal repellent that is primarily used to control wild and domestic animals from feeding on trees, shrubs and other non-food woody plants. Denatonium benzoate was of moderate acute toxicity to laboratory animals exposed via the oral route, but is extremely bitter and unlikely to be ingested in any appreciable amount by humans. It was of low acute toxicity to animals exposed by either the inhalation or dermal route. Denatonium benzoate was not irritating to the eyes or skin and is not considered to be a skin sensitizer.
Post application Non-Occupational Exposure and Risk Assessment
Non-occupational post-application exposure may occur from the use of denatonium benzoate in residential settings; however, exposure is expected to be minimal given the use scenario, timing of application and low likelihood of contact with sprayed areas. Current label instructions restrict entry into treated sites until spray has dried.
Incidental oral exposure (for example, hand-to-mouth exposure) from treated plants and outdoor household items is expected to be very minimal as denatonium benzoate is a bittering agent used to make harmful household chemicals less palatable for children.
The available database was sufficient to conclude that there is a very low level of concern for the hazard following exposure to denatonium benzoate and hence toxicokinetic study was considered for waiver in the absence of any data related to toxicokinetics of Denatonium Benzoate.
Since Denatonium benzoate is extremely bitter and unlikely to be ingested in any appreciable amount by humans. It was of low acute toxicity to animals exposed by either the inhalation or dermal route. Thus, the chemical is expected to have low bioaccumulation potential, if ingested.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Denatonium benzoate is extremely bitter and unlikely to be ingested in any appreciable amount by humans. It was of low acute toxicity to animals exposed by either the inhalation or dermal route. Thus, the chemical is expected to have low bioaccumulation potential, if ingested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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