Registration Dossier
Registration Dossier
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EC number: 241-893-9 | CAS number: 17976-32-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies are availabe for 3-methoxyestra-2,5(10)-dien-17-one (CAS number17976-32-8). Results 'read across' from studies with 3-methoxyestra-2,5(10)-dien-17ß-ol (CAS number1091-93-6) based on structural similarities as justified in the internal communication by R. Länge to J. Polomski (June 9, 2000).
The acute oral toxicity of the analogue was low with a LD50 value exceeding 2000 mg/kg bw in rats according to OECD TG 423. At the limit-dose 2000 mg/kg no animal died and no clinical signs, effects on body weight gain or gross pathological findings were observed during the 14-day post observation period.
The acute dermal toxicity of analogue was low with a LD50 value exceeding 2000 mg/kg bw in rats according to OECD TG 402. At the limit-dose 2000 mg/kg no animal died and no clinical signs, effects on body weight gain or gross pathological findings were observed during the 14-day post observation period.
Justification for classification or non-classification
Based on the study results of the analogue a classification according to Directive 67/548/EEC or Regulation (EC) No. 1272/2008 (CLP) is not warranted.
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