Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 304-661-9 | CAS number: 94277-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and OECD guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
- EC Number:
- 304-661-9
- EC Name:
- Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
- Cas Number:
- 94277-77-7
- Molecular formula:
- C65 H84 Cu N11 O12 S4 .C11 H25 N O .H
- IUPAC Name:
- copper(2+) hydrogen 3-[(2-ethylhexyl)oxy]propan-1-amine 14,24,32-tris({[({3-[(2-ethylhexyl)oxy]propyl}amino)oxy]sulfonyl})-2,11,20,29,37,38,39,40-octaazanonacyclo[28.6.1.1³,¹⁰.1¹²,¹⁹.1²¹,²⁸.0⁴,⁹.0¹³,¹⁸.0²²,²⁷.0³¹,³⁶]tetraconta-1,3(40),4,6,8,10,12,14,16,18,20,22,24,26,28(38),29,31,33,35-nonadecaene-37,39-diide-5-sulfonate
- Details on test material:
- - Substance type: blue solid
- Physical state: solid
- Purity: UBCB substance (100%)
- Purity test date: 2014
- Lot/batch No.: 070037P040
- Expiration date of the lot/batch: 01 January 2018
- Stability under test conditions: stable
- Storage condition of test material: at room temperature
- Other: The test substance appeared to be homogeneous.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 15.9 - 19.3 g
- Housing: all animals in one group were housed in a cage together as a group
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 45 – 65%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 2014-06-24 to 2014-07-29
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 5, 10, 25 % (w/w).
- No. of animals per dose:
- 5
- Details on study design:
- RANGE FINDING TESTS:
- Compound solubility: max 25% in DMF (suspension)
- Irritation: none (blue staining)
- Lymph node proliferation response:
MAIN STUDY
ANIMAL ASSIGNMENT AND TREATMENT
- Name of test method: standard H-Methylthymidine incorporation
- Criteria used to consider a positive response: SI > 3
TREATMENT PREPARATION AND ADMINISTRATION: Each test group of mice was treated by topical (epidermal) application to the dorsal surface
of each ear with test item in dimethylformamide. The application volume, 25 μL/ear/day, was spread over the entire dorsal surface (diameter 8 mm) of each ear once daily for three consecutive days. A further group of mice (control animals) was treated with an equivalent volume of the relevant vehicle alone. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 1.95 (25%) - 1.74 (10%) - 1.8 (5%)
Any other information on results incl. tables
Lymph Node Cell Counts after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Lymph Node Cell Count x10E06 per animal |
Mean Lymph Node Cell Count x10E06 per animal |
SD | Index (Value Test Group versus Value Control |
Vehicle Control (DMF) | 1 | 6.21 | 9.7 | 2.3 | 1.00 |
2 | 10.16 | ||||
3 | 11.23 | ||||
4 | 12.12 | ||||
5 | 8.70 | ||||
5 | 6 | 9.45 | 13.1 | 7.7 | 1.35 |
7 | 9.61 | ||||
8 | 26.84 | ||||
9 | 9.58 | ||||
10 | 9.92 | ||||
10 | 11 | 10.44 | 11.9 | 2.2 | 1.23 |
12 | 9.71 | ||||
13 | 15.17 | ||||
14 | 13.26 | ||||
15 | 11.02 | ||||
25 | 16 | 10.99 | 13.9 | 2.7 | 1.43 |
17 | 13.37 | ||||
18 | 17.81 | ||||
19 | 15.12 | ||||
20 | 12.14 |
Ear Weights after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Ear weight mg per animal |
Mean Ear weight (mg) | SD | Index (Value Test Group versus Value Control) |
Vehicle Control (DMF) | 1 | 24.22 | 27.0 | 1.9 | 1.00 |
2 | 27.56 | ||||
3 | 27.88 | ||||
4 | 26.40 | ||||
5 | 29.15 | ||||
5.0% | 6 | 29.12 | 27.8 | 1.2 | 1.03 |
7 | 28.20 | ||||
8 | 26.06 | ||||
9 | 28.49 | ||||
10 | 27.05 | ||||
10% | 11 | 25.74 | 26.9 | 1.9 | 1.00 |
12 | 24.36 | ||||
13 | 29.02 | ||||
14 | 28.01 | ||||
15 | 27.41 | ||||
25% | 16 | 26.33 | 27.2 | 1.6 | 1.01 |
17 | 29.49 | ||||
18 | 28.08 | ||||
19 | 26.31 | ||||
20 | 25.71 |
Lymph Node Weights after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Lymph Node weight mg per animal |
Mean Lymph Node weight (mg) | SD | Index (Value Test Group versus Value Control |
Vehicle Control (DMF) | 6 | 4.89 | 5.6 | 0.7 | 1.00 |
7 | 5.32 | ||||
8 | 6.29 | ||||
9 | 6.36 | ||||
10 | 5.14 | ||||
5 | 16 | 5.45 | 5.5 | 0.3 | 0.98 |
17 | 5.63 | ||||
18 | 5.03 | ||||
19 | 5.60 | ||||
20 | 5.78 | ||||
10 | 21 | 6.23 | 6.5 | 1.1 | 1.16 |
22 | 5.40 | ||||
23 | 8.16 | ||||
24 | 7.04 | ||||
25 | 5.58 | ||||
25 | 26 | 6.71 | 6.4 | 0.8 | 1.14 |
27 | 6.39 | ||||
28 | 7.27 | ||||
29 | 6.50 | ||||
30 | 5.13 |
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.