Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 690-796-1 | CAS number: 420-16-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No study data is available for the test substance. Effects on microorganisms were studied using the read across substance boric acid (CAS No 10043-35-3) and acetonitrile (CAS No 75-05-8). In a weight of evidence approach the toxicity of the read across substance was evaluated.
WoE (publication; Guhl, 2000; boric acid)
Opercularia birmarginata was used by Guhl (2000) in order to estimate the toxicity of boric acid. This test was carried out based on a protocol similar to the one used and described by Bringman & Kuhn, 1980. Up to 10 mg B/L, no effect was observed on the organisms. Up to 20 mg/L, on only deformations were observed but at a concentration higher or equal to 20 mg B/L, effects relative to the colony were observed.
WoE (overview of public references (1976 -2001); focus on boron)
Effects of boric acid on micro-organisms was estimated using the standardized OECD 209 method, Hanstvelt and Schoonmade (2001) reported 24% inhibition at 175 mg B/L, and an EC10 can be calculated from their data as 58 mg B/L. A NOEC was reported by the study authors of 17.5 mg B/L, but was not determined via any statistical means. Actually there was 4% inhibition at this exposure, so it is an EC4, thus more stringent than intended by the OECD 209 protocol. An EC10 value was calculated by linear regression from the data which showed a good fit (R2= 0.863) with a value of 58.0 mg B/L. This study complies with GLP practice, is rated as highly reliable in quality, and is consistent with earlier tests of activated sludge, however they were not published.
Gerike et al.(1976), using an earlier version of the OECD activated sludge method reported LOEC and NOEC of 120 and 20 mg B/L, respectively. Guhl (1992, 2000) reported activated sludge LOEC and NOEC of 50 and 20 mg B/L, respectively.
Other reports include tests of the microbe, Pseudomonas putida, with NOEC values ranging from 7.6 to 1040 mg B/L. However, these study reports are of varying reliability.
WoE (study, INEOS Nitriles, 2009, acetonitrile)
Acetonitrile was tested in an Activated Sludge Respiration Inhibition Test according to OECD guideline no. 209 ad GLP. The NOEC (30 min) for acetonitrile was determined to be 320 mg/L. This study was a standard test.
Conclusion:
Considering all cited NOEC values the worst case result for the
toxicity to microorganism is 20 mg B/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.