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EC number: 607-233-2 | CAS number: 2343-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18/5/15 to 4/6/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- methyl 2-fluoroprop-2-enoate
- EC Number:
- 607-233-2
- Cas Number:
- 2343-89-7
- Molecular formula:
- C4H5FO2
- IUPAC Name:
- methyl 2-fluoroprop-2-enoate
- Test material form:
- other: Light brown liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-Propenoic acid, 2-fluoro, methyl ester, EC Number: 607-233-2
- Physical state: Light brown liquid
- Analytical purity: 98.7%
- Lot/batch No.: 03026-20140801
- Expiration date of the lot/batch: 27 August 2015
- Storage condition of test material: Approximately 4 °C in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd.
- Age at study initiation: 12 to 20 weeks
- Weight at study initiation: 2.6 to 2.8 kg
- Housing: Individual suspended cages
- Diet (e.g. ad libitum): ad libitum, 2930C Teklad Global Rabbit diet
- Water (e.g. ad libitum): ad libitum, mains drinking water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23 °C
- Humidity (%): 30 to 70%
- Air changes (per hr): 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours darkness, 12 hours light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Tested animals were also used as control - test item was adminstered to only one eye, with the other left untreated for control purposes.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- Eight hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- Three
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- No corneal or iridial effects were noted in any animal during the study. Moderate conjunctival irritation was seen in two animals at one hour and minimal conjunctival irritation was seen in one animal at one hour. Minimal conjuctival irritation was seen at 24 hours and 48 hours. No effects were seen at 72 hours in the surviving animals.
- Other effects:
- The first treated animal was found dead three days after test substance application and the third animal was found dead two days after application.
Any other information on results incl. tables
Individual scores for Ocular Irritation
Rabbit name and sex | 75066 Male | 75073 Male | 75083 Male | ||||||||
IPR | 0 | 0 | 0 | ||||||||
Time after treatment | 1 hour | 24 hours | 48 hours | 72 hours | 1 hour | 24 hours | 48 hours | 72 hours | 1 hour | 24 hours | 48 hours |
Cornea | |||||||||||
Degree of Opacity | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
Area of Cornea Involved | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
Conjunctivae | |||||||||||
Redness | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 2 | 1 | - |
Chemosis | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | - |
Discharge | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | - |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not classified as corrosive or irritant based on the results of this study. It is not clear whether the mortalities noted on the study were test substance related.
- Executive summary:
A study has been undertaken according to OECD method 405 and EU method B5 to determine the eye irritancy of 2 -Propenoic acid, 2 -fluoro-, methyl ester. The study shows that the test item does not meet the criteria for classification according to Regulation (EC) No. 1272/2008. It is not clear whether the observed mortalities within the study are test substance related.
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