Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-005-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, in-house validated procedure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Direct peptide binding assay (DPRA) performed as described in Bauch C. et al. (2011), Toxicology in Vitro 25, 1162 – 1168.
- Principles of method if other than guideline:
- Binding to Cysteine and Lysine containing model peptides in chemico
- GLP compliance:
- yes
- Type of study:
- other: Direct peptide binding assay
Test material
- Reference substance name:
- Reaction product of Saccharose, Glycerine, biodiesel propoxylated
- EC Number:
- 940-005-3
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction product of Saccharose, Glycerine, biodiesel propoxylated
- Details on test material:
- Test substance no.: 13/0453-1
Batch ID: T41/012/13
Purity: 100% UVCB substance
Homogeneity: The test substance was homogenous by visual inspection.
Molecular weight: The test substance is an UVCB substance unknown or variable composition, complex reaction products or biological materials. In agreement with the sponsor a molecular weight of 700 g/mol was used for calculation of the test substance preparation.
Constituent 1
In vivo test system
Test animals
- Species:
- other: synthetic peptides (Cysteine- (C-) containing peptide: Ac-RFAACAA-COOH; Lysine- (K-) containing peptide: Ac-RFAAKAA-COOH)
Study design: in vivo (non-LLNA)
Induction
- Vehicle:
- other: acetonitrile
Challenge
- Vehicle:
- other: acetonitrile
Results and discussion
- Positive control results:
- EGDMA caused depletion of both peptides in all samples.
Any other information on results incl. tables
The test substance was soluble in acetonitrile. However, mixed with the peptide stock solutions, the samples were emulsions. Visual observation after the 24-hour incubation time revealed emulsions of all samples of test substance with both peptides, still. Thus the samples of both peptides and the co-elution controls were centrifuged prior to HPLC analysis. No co-elution of test substance and peptides was noticed.
The mean Cysteine-peptide depletion, caused by the test substance was determined to be 0.46 %. The mean Lysine-peptide depletion, caused by the test substance was determined to be -0.98 %. Negative depletions were considered to be “zero” for calculation of the mean peptide depletion, which was thus calculated to be 0.23 %. No co-elution of test substance and peptides was noticed. The positive control substance caused depletion of both peptides comparable to historical control data.
Applicant's summary and conclusion
- Interpretation of results:
- other: Minimal peptide binding
- Conclusions:
- Based on the observed results and applying the prediction model proposed in Gerberick et al. it was concluded that Reaction product of Saccharose, Glycerine, biodiesel propoxylated shows a minimal chemical reactivity in the DPRA under the test conditions chosen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.