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EC number: 205-619-1 | CAS number: 144-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2,4-trimethylpentane-1,3-diol
- EC Number:
- 205-619-1
- EC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Cas Number:
- 144-19-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Details on test material:
- - Name of test material (as cited in study report): 2,2,4-Trimethyl-1,3-pentanediol or TMPD
- Physical state: white solid
- Analytical purity: 99%
- Purity test date: 2000-11-6
- Lot/batch No.: 021500
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At test start (time 0), the exposure solutions were prepared, physical parameters were measured, and samples were collected for concentration verification. At test end, (time 48-hours) physical parameters of each exposure solution were measured and samples were collected for analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Replicate exposure solutions (A&B) were prepared at a nominal concentration of 110 mg/L by the addition of the appropriate amount of test substance to a 1000-mL volumetric flask brought to volume with dilution water. The test substance solution was sonicated for approximately 5 minutes to enhance the dissolution of the test substance. After sonication, the flask was inverted several times to ensure mixing. Aliquots (200 mL) of the exposure solution were then transferred to the daphnid test vessels.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Adult Daphnia magna were reared within 100-L culturing tanks located within the Testing Facility. The gravid daphnids used to produce the test animals for the study were obtained from rearing tanks which had been established for at least two weeks. Prior to the study, approximately 100 gravid daphnids were transferred by net into two glass bowls containing diluent water and food. After approximately 24 hours, all of the adult daphnids were removed from the bowls using nets and pipettes and the neonates were used for testing.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 130 mg/L
- Test temperature:
- The temperatures of the exposure solutions in all vessels ranged from 20-21°C throughout the test.
- pH:
- The pH values ranged from 8.4 to 8.5.
- Dissolved oxygen:
- The dissolved oxygen values ranged from 8.7 to 9.0 mg/L.
- Nominal and measured concentrations:
- 110 mg/L nominal and 109.1 geometric mean measured
- Details on test conditions:
- At test start (time 0), the exposure solutions were prepared, physical parameters were measured, and samples were collected for concentration verification. Ten test organisms were then introduced into each replicate test vessel. Stratified randomization was accomplished by alJocating to each vessel no more than 50% of any one set of test organisms at a time. Observations for signs of immobility and stress were made at times 0, 24, and 48 hours. At test end, (time 48-hours) physical parameters of each exposure solution were measured and samples were collected for analysis.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 109.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 109.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No immobility was observed in Daphnia in both the control and test substance throughout the exposure.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The acute toxicity of the test substance to Daphnia magna was determined in a 48-hour, static, aquatic effects limit test. The mean analyzed value for the test substance exposure concentration was determined to be 109.1 mg/L. Concentration verification was performed using gas chromatography with flame ionization detection (GC/FID). The test substance exposure concentration was calculated by averaging the geometric means (for replicates A and B) of the test substance analytical results at test start (time 0) and test end (time-48 hours). The 24- and 48-hour EC50 values for Daphnia magna were estimated to be> 109.1 mg/L. The highest tested concentration causing no immobility within the period of the test was determined to be 109.1 mg/L. The daphnids in the dilution water controls exhibited normal behavior and appearance throughout the test. No immobility was observed during this study.
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