Registration Dossier
Registration Dossier
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EC number: 240-032-4 | CAS number: 15894-70-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A short-term toxicity test with Rainbow trout (Oncorhynchus mykiss) resulted in LC50 >13mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 13 mg/L
Additional information
A reliable (Klimisch 1) short-term toxicity study with fish have been conducted HMBDA and is included in this dossier.
Holland et al. (1993) conducted a reliable (Klimisch 1) GLP compliant study following OECD 203 methods. Rainbow trout (Oncorhynchus mykiss), with weights ranging from 0.83-1.4g at the end of the study, were exposed to nominal concentrations of 10, 18, 36, 52, 100 mg/L HMBDA or measured concentrations of 2.9, 4.2, 6.2, 8.9, 13 mg/L HMBDA in a static test system for 96 hours.. Low analytical recovery was due to low solubility of the test substance. However, study authors concluded that the low solubility did not affect test outcome. The 96-hr LC50, based on mortality, was >13 mg/L.
Adequate reliable measured data exists for short-term toxicity to fish for HMBDA and has been documented within this dossier. The most reliable study result for the test substance has been identified as a study (Holland et al. 1993) which reports an LC50 for short term toxicity in fish of >13 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for HMBDA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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