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Diss Factsheets
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EC number: 203-470-7 | CAS number: 107-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed publication. Method used in study is similar to OECD 401, but this study predates GLP and individual animal data are not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of allyl alcohol.
- Author:
- Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
- Year:
- 1 958
- Bibliographic source:
- AMA Archives of Industrial Health. 18:303-311
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- individual animal responses not given, males only
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
- Details on test material:
- Allyl alcohol provided by the Shell Chemical Company
Purity: 98.5% (Impurities are diallyl ether and water)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 111 - 143 grams and 170 - 252 grams.
- Housing: groups of 5-6 in one cage
- Diet (e.g. ad libitum): standard pellets ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- Intragastric administration using ball-point needle and syringe to introduce fluid into the stomach.
- Doses:
- Various doses (unspecified) of allyl alcohol, 1% in distilled water, were given to groups of 5 male rats.
- No. of animals per sex per dose:
- 5 males rats per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: not less than 10 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology, gross pathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 105 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: For animals weighing 111-143 g
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 99 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: For animals weighing 170-252 g
- Mortality:
- No details
- Clinical signs:
- other: The main clinical sign was described as apathy along with anxiety. Lacrimation and tremors were noted in some rats. Coma and diarrhoea preceded death in moribund animals.
- Gross pathology:
- Oedema and congestion of the lungs, visceral congestion, presence of mucous in the intestinal tract, discoloured liver (some necrosis), swollen discoloured kidneys.
- Other findings:
- Histopathological examination showed lung congestion, liver damage (congestion and necrosis of periportal sinusoids, central pallor and necrosis), presence of heme casts and a cloudy swelling in the kidney. Rats surviving the 10 day observation period showed similar lesions to rats that had died, but less frequently.
Any other information on results incl. tables
The LD50 values were calculated according to Weil's modification according to the method of Thompson. 95% confidence limits were not reported.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study the LD50 of allyl alcohol is between 99 - 105 mg/kg bw in rats.
- Executive summary:
In an acute oral toxicity study, groups of 5 male long-evan rats were given a single oral dose of graded quantities of allyl alcohol solution and observed for 10 days.
Oral LD50Males = 99 - 105 mg/kg bw
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