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EC number: 406-080-7 | CAS number: 83016-70-0 JEFFCAT ZF-10; TEXACAT ZF-10
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-10-05 to 1983-11-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Well documented scientifically sound acute dermal study similar to OECD guidelines and following GLP. The skin of one male and one female from each dose group was abraded prior to treatment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Skin of 1 male and 1 female in each group was abraded
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 5601-22-20
- Physical state: Light yellow liquid
- Stability under test conditions: There was no apparent change in the physical state of the test article during administration
- Other: Base factor: Specific gravity = 0.952 g/ml; 1 quart supplied on September 26, 1983; the purity of the test article was the responsibility of the sponsor
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sgarlat's Rabbitry, Harvey's Lake, PA and Perfection Breeders, Douglassville, PA
- Weight at study initiation: 2 - 3 kg
- Housing: Animals were housed individually in cages sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of the Institute of Laboratory Resources, National Research Council.
- Diet: Wayne Rabbit RationR, ad libitum
- Water: Fresh tap water, suitable for human consumption, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-3
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No less than 20% of the dorsal body surface area
- Type of wrap if used: A layer of gauze covering the dosed area; animals were then wrapped with rubber dam and an ace bandage to retard evaporation.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 h
- Doses:
- 4000, 5000, 6300, 8000 mg/kg
- No. of animals per sex per dose:
- 2 per sex per dose (16 in total), the skin of one male and one female from each dose group was abraded prior to test substance application.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 30 minutes, 2 and 4 hours after the 24 hour exposure period, and twice daily thereafter for 14 days.
- Necropsy of survivors performed: yes - Statistics:
- By the method of Litchfield and Wilcoxon (1949) JPET 96:99-114
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 700 mg/kg bw
- 95% CL:
- 4 400 - 7 300
- Mortality:
- Male: 4000 mg/kg bw; Number of animals: 2; Number of deaths: 0
Male: 5000 mg/kg bw; Number of animals: 2; Number of deaths: 1
Male: 6300 mg/kg bw; Number of animals: 2; Number of deaths: 2
Male: 8000 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 4000 mg/kg bw; Number of animals: 2; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 6300 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 8000 mg/kg bw; Number of animals: 2; Number of deaths: 2 - Clinical signs:
- other: None of the rabbits died at 4 g/kg, two of four rabbits died at 5 g/kg and three of four died at 6.3 and 8 g/kg. Signs observed included necrosis, severe to moderate erythema and edema of the application sites and surrounding areas, decreased activity, ab
- Gross pathology:
- Necropsy of animals dying on study revealed pale livers with necrotic areas on all lobes. Pale kidneys and hemorrhages of the muscle layers underlying the application sites were also observed.
Terminal necropsy revealed hemorrhages of the muscle layers under the application sites.
Any other information on results incl. tables
No notation regarding effects of abrasion were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The calculated LD50 for the test material was determined to be 5700 mg/kg with 95% confidence limits of 4400 to 7300 mg/kg. The substance is considered not classified as acute dermal toxicant.
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